463335-96-8

Usage

Uses

Used in Organic Synthesis:
2-Cyano-5-fluorophenylboronic acid pinacol ester is used as a reagent in organic synthesis for facilitating Suzuki and Heck cross-coupling reactions. These reactions are essential for creating carbon-carbon bonds, which are fundamental in the construction of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Cyano-5-fluorophenylboronic acid pinacol ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to form stable complexes with diols makes it a valuable tool for the selective recognition and binding of biological molecules, which is crucial for the development of targeted drug therapies.
Used in Chemical Synthesis:
2-Cyano-5-fluorophenylboronic acid pinacol ester is employed as a versatile building block in chemical synthesis. Its pinacol ester moiety enhances its solubility and stability, making it easier to handle and store, which is beneficial for the synthesis of a wide range of chemical compounds.
Used in Drug Development:
2-Cyano-5-fluorophenylboronic acid pinacol ester is utilized in drug development for its potential to create new pharmaceutical agents. Its unique properties, such as its ability to form stable complexes with diols and participate in cross-coupling reactions, make it a promising candidate for the development of innovative drugs with improved efficacy and selectivity.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 36282-26-5 2-bromo-4-fluorobenzonitrile 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 463335-98-0 4-fluoro-2-(6-bromopyridin-2-yl)benzonitrile 
• 731817-83-7 4-fluoro-2-(3-fluoropyridin-2-yl)benzonitrile 
• 765916-89-0 5,2'-difluoro-5'-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile 

Relevant academic research and scientific papers

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

Designing dual emitting cores for highly efficient thermally activated delayed fluorescent emitters

Improving the efficiency and the stability of TADF-based OLED devices is of vital importance for OLED applications. In this work, two dual emitting cores (2,2′-DPXZ-PN and 3,3′-DPXZ-PN) were rationally synthesized by connecting two identical TADF emitting

Iridium complexes of N-heterocyclic carbenes in C-H borylation using energy efficient microwave technology: Influence of structure, ligand donor strength and counter ion on catalytic activity

Bridged and unbridged N-heterocyclic carbene (NHC) ligands were metalated with [Ir(COD)Cl]2 to give iridium(i) mono- and biscarbene substituted catalysts [Ir(COD)NHC(Cl)] and [Ir(COD)(NHC)2][X] (X: I, PF 6, BF4, CF3COO, OTf). The prepared NHC-complexes were tested in the C-H borylation reaction of aromatic carbons with bis(pinacolato)diboron (B2pin2) and pinacolborane (HBpin). The use of microwave technology in this study not only facilitates a time efficient screening of a wide range of influences such as ligand σ-donor strength and structural motif as well as the effects of the complex counter ion, but also provides an energy efficient heating source. Catalyst 6TFA, which features a chelating NHC ligand, proved to be most effective catalyst and further investigations with this complex in the borylation of mono- and disubstituted benzene derivatives exploring chemo- and regioselectivity were undertaken. The Royal Society of Chemistry 2009.

Process for producing cyano substituted arene boranes and compounds

A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.

Sterically directed functionalization of aromatic C-H bonds: Selective borylation ortho to cyano groups in arenes and heterocycles

Ir-catalyzed borylations of 4-substituted benzonitriles are described. In contrast to electrophilic aromatic substitutions and directed ortho metalations, C-H activation/borylation enables functionalization at the 2-position, adjacent to the cyano group, when the 4-subsitutent is larger than cyano. When an excess of borane reagent is used, diborylation can be achieved with a single regioisomer being formed in certain cases. Extension of sterically directed borylation to cyano-substituted, five- and six-membered ring heterocycles is also reported.

FLUOROIMIDAZOPYRIMIDINES AS GABA-A ALPHA 2/3 LIGANDS FOR DEPRESSION/ANXIETY

The present invention provides a compound formula (I), or a pharmaceutically acceptable salt thereof: wherein W is phenyl or pyridyl; X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2/su

Imidazo[4,5-c]pyridin-4-one analogues as GABAA receptor ligands

A compound of formula I, or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen; Y represents a chem

8-FLUORIMIDAZO`1,2-A!PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoroimidazo[1,2-a]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.