463336-62-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-6-imidazol-1-yl-pyridine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, incorporating elements from both the pyridine and imidazole groups, makes it a promising candidate for the development of new drugs with potential applications in treating various diseases.
Used in Dye Manufacturing:
2-Bromo-6-imidazol-1-yl-pyridine is used as a key component in the production of dyes. Its chemical properties, including the presence of a bromine atom, contribute to the color and stability of the resulting dyes, making it a valuable asset in the dye manufacturing process.
Used in Biological Research:
2-Bromo-6-imidazol-1-yl-pyridine is used as a research tool in biological studies. Its incorporation of both pyridine and imidazole groups allows for the exploration of its interactions with biological molecules, potentially leading to new insights into the mechanisms of various biological processes.
Note: The uses listed above are speculative based on the information provided and the general properties of compounds with similar structures. Further research and experimentation would be necessary to confirm the specific applications and benefits of 2-bromo-6-imidazol-1-yl-pyridine in these industries.

Upstream product

• 288-32-4 1H-imidazole 
• 626-05-1 2,6-Dibromopyridine 
• 144100-07-2 2-bromo-6-fluoropyridine 

Downstream Products

• 1220596-09-7 benzyl 2-(6-(1H-imidazol-1-yl)pyridin-2-yl)ethylcarbamate 

Relevant academic research and scientific papers

Pyridine-bridged bifunctional organocatalysts for the synthesis of cyclic carbonates from carbon dioxide

Hydroxyl- and carboxyl-functionalized imidazolium halides are used as efficient bifunctional organocatalysts for the synthesis of cyclic carbonates from CO2 and epoxides under mild reaction conditions. Control experiments suggest that the cycloaddition reaction is realized by the combination of the nucleophilic halide anions with hydroxyl and carboxyl groups as hydrogen bond donors. Moreover, the bifunctional organocatalysts can be easily recycled five times by simple filtration; however, a loss of activity was observed.

Counteranion-Controlled Ag2O-Mediated Benzimidazolium Ring Opening and Its Application in the Synthesis of Palladium Pincer-Type Complexes

We report a new approach to synthesize palladium complexes through Ag2O-promoted hydrolytic ring opening followed by palladium coordination. The novelty of Ag2O-promoted hydrolysis in comparison with the commonly used base-mediated hydrolysis lies in the anion-controlled product selectivity in the synthesis of pincer-type palladium complexes. Moreover, these palladium complexes have been tested in the Suzuki reaction using aryl bromides in methanol and H2O, respectively. In comparison with palladium complexes with normal coordination, the palladium complexes generated from the hydrolytic ring-opening coordination demonstrate excellent catalytic activity.

Metal-free site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines

This paper presents a metal-free method for highly site-selective C-N bond-forming reaction of polyhalogenated pyridines and pyrimidines. The preferred coupling site can be tuned from the fluorine group bearing the N-heterocyclic ring to the chlorine group when changing from the pyridine ring to the pyrimidine ring. A wide array of halogenated pyridines preferentially reacted with amines at the fluorine group of the pyridine ring to generate monosubstituted halogenated pyridines with high selectivities. Different halogen atoms at various positions were produced by the pyridine ring that performed well under mild conditions. Halogenated pyrimidines underwent highly selective coupling at the chloride group with a wide range of amines having broad substrate applicability and moderate to good yields. The selectivity of the polyfluoropyridines in the developed reaction system was also tested, and the result indicated that the reaction occurred site-selectively at the ortho-position of the nitrogen ring. This reaction accommodated a wide range of halogenated groups. Thus, a wide range of chloro-, bromo-, iodo-, and fluoropyridines were generated, which have a wide utility for organic synthesis.

Selective C-N bond-forming reaction of 2,6-dibromopyridine with amines

A practical and efficient protocol for the syntheses of 6-substituted 2-bromopyridine compounds has been developed by using a selective copper-catalyzed C-N bond-forming reaction between 2,6-dibromopyridine and a range of amines. The major advantage of this protocol is the complete control of selectivity of the pyridine bromine atom for the C-N cross-coupling reaction. There are few reported syntheses of unsymmetrical 2,6-disubstituted pyridine-bridged compounds because of their complicated preparations. Although this is the case, a new series of these unsymmetrical compounds have been successfully prepared in two steps by using this copper-catalyzed coupling approach. A practical protocol for the syntheses of 6-substituted 2-bromopyridine compounds has been developed by using a selective copper-catalyzed coupling reaction of 2,6-dibromopyridine with a range of amines.

Role of copper in catalyzing aryl and heteroaryl-nitrogen (or -oxygen) bond formation under ligand-free and solvent-free conditions

Formation of aryl- or heteroaryl-nitrogen (or -oxygen) bonds under ligand and solvent-free conditions are highly selective to the presence of copper. While bromoarenes undergo C-N (or -O) coupling in stoichiometric presence of copper, heteroaryl bromides require only catalytic amounts of copper(I) salts depending on the position of bromo substituents. Such selectivity coupled with ligand and solvent-free protocols appear promising from the viewpoint of ecology and economy and are more attractive as compared to the existing protocols.