463355-58-0

Basic information

• Product Name: 3-chloro-3',4'-dihydroxydiphenylmethanone
• CAS NO: 463355-58-0
• Molecular Weight: 248.666
• Mol File: 463355-58-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-chloro-3',4'-dihydroxydiphenylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-3',4'-dihydroxydiphenylmethanone(463355-58-0)
• EPA Substance Registry System: 3-chloro-3',4'-dihydroxydiphenylmethanone(463355-58-0)

Safety Data

• Hazardous Substances Data: 463355-58-0(Hazardous Substances Data)

Upstream product

• 116412-84-1 3-chloro-3',4'-dimethoxydiphenylmethanone 

Relevant articles and documents

Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents

A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3′-dibromo-4,5,6′-trihydroxydiphenylmethanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H2O2-induced injury in HUVEC with EC50 values of 0.4 and 0.8 μM, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities.