463356-00-5 Usage
Uses
Used in Antifungal Applications:
Sordarin sodium salt is used as an antifungal agent for its selective inhibition of fungal protein synthesis. It effectively inhibits the growth of C. albicans at a minimal inhibitory concentration (MIC) of 8 μg/ml. This selective action makes sordarin sodium salt a potential candidate for treating fungal infections, particularly those caused by Candida species.
Used in Pharmaceutical Research:
Sordarin sodium salt is used as a research tool for studying the mechanisms of fungal protein synthesis and the role of elongation factor 2 (EF-2) in this process. Its selective inhibition of EF-2 in fungi, as opposed to mammalian cells, makes it a valuable compound for understanding the differences in protein synthesis between fungi and higher eukaryotes.
Used in Drug Development:
Sordarin sodium salt is used as a lead compound in the development of new antifungal drugs. Its potent activity against specific Candida species and its selective targeting of EF-2 offer opportunities for designing more effective and targeted antifungal therapies, especially for drug-resistant infections.
Biochem/physiol Actions
Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C.?albicans, C.?glabrata, and C.?neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.
Check Digit Verification of cas no
The CAS Registry Mumber 463356-00-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,3,3,5 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 463356-00:
(8*4)+(7*6)+(6*3)+(5*3)+(4*5)+(3*6)+(2*0)+(1*0)=145
145 % 10 = 5
So 463356-00-5 is a valid CAS Registry Number.
