4635-81-8 Usage
Uses
Used in Organic Synthesis:
2-(biphenyl-2-yl)propan-2-ol is used as a building block in the synthesis of pharmaceuticals and other organic compounds due to its ability to be incorporated into complex molecular structures.
Used in Asymmetric Synthesis:
As a chiral auxiliary, 2-(biphenyl-2-yl)propan-2-ol is utilized in asymmetric synthesis reactions to control the stereochemistry of the products, leading to the formation of enantiomerically pure compounds.
Used in Coordination Chemistry:
2-(biphenyl-2-yl)propan-2-ol serves as a ligand, playing a crucial role in the formation and stabilization of metal complexes, which are essential in various catalytic processes.
Used in Materials Science:
2-(biphenyl-2-yl)propan-2-ol has potential applications in materials science, where its unique structure and properties can contribute to the development of new materials with specific characteristics.
Used in Catalysis:
2-(biphenyl-2-yl)propan-2-ol's properties make it a candidate for use in catalysis, where it could enhance the efficiency of chemical reactions by lowering the activation energy required for the reaction to proceed.
Check Digit Verification of cas no
The CAS Registry Mumber 4635-81-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,3 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4635-81:
(6*4)+(5*6)+(4*3)+(3*5)+(2*8)+(1*1)=98
98 % 10 = 8
So 4635-81-8 is a valid CAS Registry Number.
4635-81-8Relevant academic research and scientific papers
Palladium-catalyzed arylation of α,α-disubstituted arylmethanols via cleavage of a C-C or a C-H bond to give biaryls
Terao, Yoshito,Wakui, Hiroyuki,Nomoto, Michiyo,Satoh, Tetsuya,Miura, Masahiro,Nomura, Masakatsu
, p. 5236 - 5243 (2007/10/03)
The palladium-catalyzed arylation of α,α-disubstituted arylmethanols with aryl halides proceeds not only via C-H bond cleavage at the ortho-position, but also via cleavage of the sp2-sp3 C-C bond with the liberation of ketones (β-carbon elimination) to give the corresponding biaryls. Both reactions appear to occur through common arylpalladium(II) alcoholate intermediates. The results of systematic studies with respect to which C-C or C-H bond is preferentially cleaved in the arylation are reported. Among the important findings is the selective elimination of ortho-substituted aryl groups even from aryl(diphenyl)methanols due to steric reasons. Thus, various biaryls having ortho-substituents can be produced efficiently by treatment of the corresponding aryl(diphenyl or dimethyl)methanols with aryl bromides and chlorides.
