464195-31-1

Basic information

• Product Name: glutathione, oxidized
• Synonyms: glutathione, oxidized
• CAS NO: 464195-31-1
• Molecular Weight: 612.639
• Mol File: 464195-31-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: glutathione, oxidized(CAS DataBase Reference)
• NIST Chemistry Reference: glutathione, oxidized(464195-31-1)
• EPA Substance Registry System: glutathione, oxidized(464195-31-1)

Safety Data

• Hazardous Substances Data: 464195-31-1(Hazardous Substances Data)

Upstream product

• 128960-77-0 glutathione 
• 131549-85-4 nitroso derivative of sulfamethoxazole 
• 70-18-8 GLUTATHIONE 
• 7722-84-1 dihydrogen peroxide 

Relevant articles and documents

Controlled nitric oxide delivery platform based on S-nitrosothiol conjugated interpolymer complexes for diabetic wound healing

Nitric oxide (NO) is known to play a critical role in enhancing wound healing as topical NO administration has demonstrated enhanced wound healing in diabetic animal models. However, this approach has been limited by the short duration of NO release, short half-life of NO, and instability of available NO donors. To overcome these deficiencies, we have developed a new NO delivery platform based on grafting S-nitrosothiols (RSNOs), derived from endogenous glutathione (GSH) or its oligomeric derivatives, phytochelatins (PCs), onto poly(vinyl methyl etherco-maleic anhydride) (PVMMA), and their subsequent formation of interpolymer complexes with poly(vinyl pyrrolidone) (PVP). Such interpolymer complexes provide controlled release of NO for an extended duration (>10 days) and exhibit enhanced stability in the solid state over that of free RSNOs. The existence of intermolecular hydrogen bonding in such complexes and the formation of disulfide bonds following the NO release have been confirmed by FTIR and Raman. Preliminary wound healing study in a diabetic rat model demonstrates that, with a single topical application, the present controlled release NO delivery system can effectively accelerate wound closure as compared with the control (p 0.05). The results suggest that the present NO releasing interpolymer complexes could be potentially useful for diabetic wound healing.

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

Sulphamethoxazole hydroxylamine (SMX-NHOH) and nitroso sulphamethoxazole (SMX-NO) were prepared by a modified literature procedure. SMX-NO produced a complex set of unstable intermediates with sulphur nucleophiles, but did not react with amino containing compounds. No reactions were observed between sulphamethoxazole (SMX) / SMX-NHOH and the nucleophiles used in this study. Thus antigens formed from N-oxidation of SMX are likely to be unstable in vivo.