4644-99-9Relevant academic research and scientific papers
An appetite suppressant from Hoodia species
van Heerden, Fanie R.,Marthinus Horak,Maharaj, Vinesh J.,Vleggaar, Robert,Senabe, Jeremiah V.,Gunning, Philip J.
, p. 2545 - 2553 (2007)
Studies conducted at the Council for Scientific and Industrial Research (CSIR, South Africa) identified extracts from Hoodia species, in particular Hoodia pilifera and Hoodia gordonii, as possessing appetite suppressing properties. Two pregnane glycosides were isolated by fractionation of the dried stems of H. gordonii. Their structures were determined as 3β-[β-d-thevetopyranosyl-(1→4)-β-d- cymaropyranosyl-(1→4)-β-d-cymaropyranosyloxy]-12β-tigloyl oxy-14β-hydroxypregn-5-en-20-one (1) and 3β-[β-d-cymaropyranosyl-(1→4)-β-d-6-thevetopyranosyl -(1→4)-β-d-cymaropyranosyl-(1→4)-β-d-cymaropyranosyl oxy]-12β-tigloyloxy-14β-hydroxypregn-5-en-20-one (2) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from H. pilifera. Compound 1 was tested for its appetite suppressant properties in rats by oral gavage at 6.25-50 mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time.
Pregnane glycosides from Hoodia gordonii
Shukla, Yatin J.,Pawar, Rahul S.,Ding, Yuanqing,Li, Xing-Cong,Ferreira, Daneel,Khan, Ikhlas A.
experimental part, p. 675 - 683 (2010/02/17)
Hoodia gordonii is a 'weight loss' herb, which has gained popularity in the western countries as an appetite suppressant dietary supplement. Phytochemical study of its aerial parts led to isolation of seven pregnane glycosides (hoodigosides W-Z, hoodistan
Pharmaceutical compositions having appetite suppressant activity
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, (2011/05/18)
A pharmaceutical composition which contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound
