46459-93-2Relevant academic research and scientific papers
Binding of 2,4-substituted morpholines at human D4 dopamine receptors
Showell, Graham A.,Emms, Frances,Marwood, Rosemarie,O'Connor, Desmond,Patel, Smita,Leeson, Paul D.
, p. 1 - 8 (2007/10/03)
The synthesis of a series of 2,4-disubstituted morpholines is described and their affinities at human dopamine receptors reported. The orally bioavailable 7-azaindole compound 11 has nanomolar affinity at the hD4 receptor with > 1000-fold selectivity over the hD2 receptor.
MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS
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, (2008/06/13)
A class of substituted morpholine derivatives of formula STR1 wherein Y represents an optionally substituted bicyclic heteroaromatic ring system containing one or two nitrogen atoms, the ring system comprising a six-membered aromatic or heteroaromatic ring fused to a five-or six-membered heteroaromatic ring; and Z represents an optionally substituted arylalkyl, aryloxymethyl or arylalkoxymethyl group, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia.
