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Phosphonic dichloride, (4-bromophenyl)-, also known as 4-bromophenylphosphonic dichloride, is an organophosphorus compound with the chemical formula C6H4BrCl2OP. It is a white crystalline solid that is soluble in organic solvents. Phosphonic dichloride, (4-bromophenyl)- is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. It is also employed in the preparation of ligands for transition metal complexes. Due to its reactivity, it is essential to handle Phosphonic dichloride, (4-bromophenyl)- with care, as it can be harmful if inhaled, ingested, or absorbed through the skin.

4648-58-2

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4648-58-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4648-58-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,4 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4648-58:
(6*4)+(5*6)+(4*4)+(3*8)+(2*5)+(1*8)=112
112 % 10 = 2
So 4648-58-2 is a valid CAS Registry Number.

4648-58-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-bromo-4-dichlorophosphorylbenzene

1.2 Other means of identification

Product number -
Other names 4-Brom-phenylphosphinsaeure-dichlorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4648-58-2 SDS

4648-58-2Relevant academic research and scientific papers

HETEROCYCLIC GLP-1 AGONISTS

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Page/Page column 184-185, (2021/08/14)

This disclosure relates to GLP-1 agonists of Formula (I) : including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Towards the next generation of dual Bcl-2/Bcl-xL inhibitors

Varnes, Jeffrey G.,Gero, Thomas,Huang, Shan,Diebold, R. Bruce,Ogoe, Claude,Grover, Paul T.,Su, Mei,Mukherjee, Prasenjit,Saeh, Jamal Carlos,Macintyre, Terry,Repik, Galina,Dillman, Keith,Byth, Kate,Russell, Daniel John,Ioannidis, Stephanos

, p. 3026 - 3033 (2014/06/24)

Structural modifications of the left-hand side of compound 1 were identified which retained or improved potent binding to Bcl-2 and Bcl-x L in in vitro biochemical assays and had strong activity in an RS4;11 apoptotic cellular assay. For example, sulfoxide diastereomer 13 maintained good binding affinity and comparable cellular potency to 1 while improving aqueous solubility. The corresponding diastereomer (14) was significantly less potent in the cell, and docking studies suggest that this is due to a stereochemical preference for the RS versus SS sulfoxide. Appending a dimethylaminoethoxy side chain (27) adjacent to the benzylic position of the biphenyl moiety of 1 improved cellular activity by approximately three-fold, and this activity was corroborated in cell lines overexpressing Bcl-2 and Bcl-xL.

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