464895-67-8Relevant academic research and scientific papers
One-Pot Conversion of Aldehydes and Ketones into 1-Substituted and 1,4-Disubstituted 1,3-Enynes
Cabezas, Jorge A.,Poveda, Rebeca R.,Brenes, José A.
, p. 3307 - 3321 (2018/09/04)
Sequential treatment of 2,3-dichloropropene with magnesium and n -BuLi generates the operational equivalent of 1,3-dilithiopropyne, which upon treatment with aldehydes or ketones, produces the corresponding alkoxy lithium acetylide intermediates. Reaction of this alkoxide with tosyl chloride, and t -BuLi produces 1-substituted, or 1,1-disubstituted 1,3-enynes in a one-pot reaction. When this lithium acetylide intermediates, obtained by this procedure, were used to perform palladium-catalyzed cross-coupling reactions, followed by addition of thionyl chloride and pyridine, 1,4-disubstituted or 1,1,4-trisubstituted 1,3-enynes were obtained in a one-pot protocol.
Increased activity of in situ catalysts for alkyne metathesis
Brizius, Glen,Bunz, Uwe H. F.
, p. 2829 - 2831 (2007/10/03)
(figure presented) Reaction of an enyne (1,1-diphenyl-pent-1-ene-3-yne) with a preheated mixture of Mo(CO)6/4-chlorophenol/3-hexyne at 130 °C furnished 1,1,6,6-tetraphenylhex-1,5-diene-3-yne in an 80% yield. If the starting material was heated
