4649-30-3

Usage

Uses

Used in Pharmaceutical Research:
1H-Isoindole-5-carboxylic acid, 2,2'-(1,4-phenylene)bis[2,3-dihydro-1,3-dioxois used as a starting material in pharmaceutical research for the synthesis of various pharmaceuticals and bioactive molecules. Its unique structure and potential biological activity make it a promising candidate for the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Isoindole-5-carboxylic acid, 2,2'-(1,4-phenylene)bis[2,3-dihydro-1,3-dioxoserves as a key intermediate for the preparation of complex organic compounds. Its presence of dihydro-1,3-dioxo and carboxylic acid groups allows for various chemical reactions, facilitating the synthesis of a wide range of organic molecules.
Used in Drug Development:
Due to its potential biological activity, 1H-Isoindole-5-carboxylic acid, 2,2'-(1,4-phenylene)bis[2,3-dihydro-1,3-dioxois utilized in drug development as a lead compound for the discovery of new therapeutic agents. Its unique chemical properties and pharmacological potential make it a valuable asset in the search for novel treatments for various diseases and conditions.

Upstream product

• 106-50-3 1,4-phenylenediamine 
• 552-30-7 trimellitic Anhydride 

Downstream Products

• 104919-42-8 C₃₀H₂₀N₂O₁₀ 
• 84072-73-1 N,N'-bis(4-allyloxycarbonylphthalimido)-1,4-benzene 

Relevant academic research and scientific papers

METHOD FOR PRODUCING BISIMIDE DICARBOXYLIC ACID

An object of the present invention is to provide an industrially advantageous method for producing a bisimide dicarboxylic acid, which uses substantially no solvent and requires no granulation after completion of the reaction. The above object can be achieved by a method for producing a bisimide dicarboxylic acid with a tricarboxylic acid anhydride and a diamine, including the following processes (i) and (ii): a process (i) in which, provided that a compound having a higher melting point is a high melting compound and a compound having a lower melting point is a low melting compound, when a melting point is compared between the tricarboxylic acid anhydride and the diamine, the high melting compound is heated at a temperature between less than the melting point of the high melting compound and not lower than the melting point of the low melting compound, and the low melting compound is added to the high melting compound while the high melting compound maintains its solid states, to give a mixture; anda process (ii) in which the resultant mixture in the process (i) is heated while its solid states are kept, to give bisimide dicarboxylic acid.

New method for synthesis of aromatic diimide dicarboxylic acid diallyl esters

New method is suggested for synthesis aromatic diimide dicarboxylic acid diallyl esters from the corresponding acids under the action of allyl halides in aprotic polar solvents in the presence of anhydrous K2CO 3.

Photoreactive copoly(amide-imide)s derived from 1,4-phenylenediacrylic acid and various bis(trimellitimide)s and diisocyanates

Three bis(trimellitimide)s were prepared by condensation of the corresponding aromatic diamines with trimellitic anhydride.Two series of structurally new photoreactive copoly(amide-imide)s were synthesized by the direct polycondensation of these bis(trimellitimide)s and 1,4-phenylenediacrylic acid as comonomer with 4,4′-diphenylmethanediisocyanate (series 1) and 1,6-diisocyanatohexane (series 2), respectively. The polycondensation reaction was carried out in N-methyl-2-pyrrolidone in the presence of tripropylamine as catalyst. All of the copoly(amide-imide)s soluble in polar aprotic solvents afforded transparent, flexible and tough films. Upon irradiation in solution the p-phenylenediacryloyl unit undergoes trans-cis photoisomerization and (2 + 2)photocycloaddition. Polymers of series 1 (all fully aromatic amides) undergo also a photo-Fries rearrangement. On the contrary, the photo-Fries reaction is completely suppressed for polymers of series 2 (containing an aliphatic amide moiety).The same situation is observed in the case of polymer films. The wholly aromatic copoly(amide-imide)s show no discernible transition before decomposition, whereas the aliphatic-aromatic copoly(amide-imide)s show well-defined melting points (Tm) in the first DSC heating traces.