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GAMABUFOTALIN, also known as bufotalin, is a toxic steroid compound derived from the skin and venom of certain toad species, particularly in the genus Bufo. It is a potent cardiac glycoside with the ability to cause severe poisoning and even death when ingested in large amounts. Its mechanism of action involves inhibiting the sodium-potassium pump, leading to increased intracellular sodium levels and interference with the heart's normal electrical activity, potentially causing arrhythmias, cardiac arrest, and other life-threatening complications. Despite its toxic nature, GAMABUFOTALIN has garnered interest for its potential medicinal properties, especially in the treatment of specific types of cancer.

465-11-2

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465-11-2 Usage

Uses

Used in Pharmaceutical Industry:
GAMABUFOTALIN is used as a potential therapeutic agent for the treatment of certain types of cancer. Its application is based on the compound's ability to target and affect cancer cells, offering a novel approach to cancer therapy.
Used in Cardiac Research:
GAMABUFOTALIN is used as a research tool to study the effects of sodium-potassium pump inhibition on cardiac function. This helps in understanding the mechanisms of action of cardiac glycosides and their impact on heart health, potentially leading to the development of safer and more effective heart medications.
Used in Toxicology Studies:
Due to its high toxicity, GAMABUFOTALIN is utilized in toxicology research to investigate the effects of poisoning and to develop antidotes or treatments for cases of accidental ingestion or exposure.

Check Digit Verification of cas no

The CAS Registry Mumber 465-11-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 5 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 465-11:
(5*4)+(4*6)+(3*5)+(2*1)+(1*1)=62
62 % 10 = 2
So 465-11-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H34O5/c1-22-9-7-16(25)11-15(22)4-5-18-21(22)19(26)12-23(2)17(8-10-24(18,23)28)14-3-6-20(27)29-13-14/h3,6,13,15-19,21,25-26,28H,4-5,7-12H2,1-2H3/t15-,16+,17-,18-,19-,21-,22+,23-,24+/m1/s1

465-11-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[(3S,5R,8R,9S,10S,11R,13R,14S,17R)-3,11,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

1.2 Other means of identification

Product number -
Other names Gamabufagin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:465-11-2 SDS

465-11-2Upstream product

465-11-2Downstream Products

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