465-90-7

Basic information

• Product Name: Hellebrigenin
• CAS NO: 465-90-7
• Molecular Formula: C₂₄H₃₂O₆
• Molecular Weight: 416.514
• Mol File: 465-90-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hellebrigenin(CAS DataBase Reference)
• NIST Chemistry Reference: Hellebrigenin(465-90-7)
• EPA Substance Registry System: Hellebrigenin(465-90-7)

Safety Data

• Hazardous Substances Data: 465-90-7(Hazardous Substances Data)

Usage

General Description

Hellebrigenin is a steroidal saponin found in the poisonous plant Helleborus niger, also known as black hellebore. It is a toxic chemical that has been traditionally used as a therapeutic agent in folk medicine to treat various medical conditions such as arthritis, gout, and edema. In scientific research, hellebrigenin has been investigated for its potential anticancer properties, as well as its ability to induce apoptosis, or programmed cell death, in cancer cells. However, its high toxicity limits its practical use in modern medicine, and its potential therapeutic benefits remain a subject of ongoing study and debate.

Upstream product

• 13289-18-4 (3β,5β)-3-[(6-deoxy-4-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-bufa-20,22-dienolide 
• 186581-53-3 diazomethane 
• 105330-48-1 3-(N-suberoylargininyl)hellebrigenin 
• 20300-44-1 5β,14β-dihydroxy-19-oxo-3β-[(α-L-rhamonopyranosyl)oxy]bufa-20,22-dienolide 

Downstream Products

• 1243276-11-0 UNBS₅₅₇₆ 
• 1243276-09-6 UNBS₅₅₅₇ 
• 26577-92-4 3β,14,19-trihydroxy-14β-bufa-4,20,22-trienolide 
• 26611-43-8 3α,14,19-trihydroxy-14β-bufa-4,20,22-trienolide 
• 21887-06-9 14-hydroxy-3,19-dioxo-14β-bufa-4,20,22-trienolide 
• 76026-50-1 D 14447 
• 67696-82-6 acrihellin 

Relevant articles and documents

Structure-activity relationship analysis of bufadienolide-induced in vitro growth inhibitory effects on mouse and human cancer cells

The in vitro growth inhibitory effects of 27 bufadienolides and eight degradation products, with two cardenolides (ouabain and digoxin) chosen as reference compounds, were analyzed by means of an MTT colorimetric assay in six human and two mouse cancer cell lines. A structure-activity analysis was then performed to highlight the most important substituents relating to the in vitro growth inhibitory activity of bufadienolides in cancer cells. Thus, the current study revealed that various bufadienolides, including gamabufotalin rhamnoside (1a), bufotalin (2a), and hellebrin (3a), displayed higher growth inhibitory activities for various human cancer cell lines when compared to ouabain and digoxin. Gamabufotalin rhamnoside (1a) was the only compound that displayed growth inhibitory effects of +,K+-ATPase α-1 subunit. In addition, all genins and degradation products displayed weaker (if any) in vitro growth inhibitory effects on cancer cells when compared to their respective glycosylated homologue, with the exception of hellebrigenin (3b), which was as active as hellebrin (3a).

Occurrence of bufadienolides in the skin of Bufo viridis Laur.

-