4650-69-5Relevant academic research and scientific papers
Synthesis and?evaluation of?cytotoxic activity of?arylfurans
de Oliveira, Renata B.,de Souza-Fagundes, Elaine M.,Siqueira, Helen A.J.,Leite, Rodrigo S.,Donnici, Claudio L.,Zani, Carlos L.
, p. 756 - 760 (2007/10/03)
A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells.
Substituted furans as inhibitors of the PDE4 enzyme
Perrier, Helene,Bayly, Christopher,Laliberte, France,Huang, Zheng,Rasori, Roberta,Robichaud, Annette,Girard, Yves,Macdonald, Dwight
, p. 323 - 326 (2007/10/03)
The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented.
