4651-92-7

Basic information

• Product Name: 2-AMINO-4-ETHYL-5-METHYL-3-THIOPHENECARBONITRILE
• Synonyms: 2-AMINO-4-ETHYL-5-METHYL-3-THIOPHENECARBONITRILE;2-AMINO-4-ETHYL-5-METHYLTHIOPHENE-3-CARBONITRILE;AKOS B000682;AKOS MSC-0405;ART-CHEM-BB B000682;CHEMBRDG-BB 4192347;2-amino-4-ethyl-5-methylthiophene-3-carbonitrile(SALTDATA: FREE)
• CAS NO: 4651-92-7
• Molecular Formula: C8H10N2S
• Molecular Weight: 166.24
• Mol File: 4651-92-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 315.9°C at 760 mmHg
• Flash Point: 144.9°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000423mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 2-AMINO-4-ETHYL-5-METHYL-3-THIOPHENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-ETHYL-5-METHYL-3-THIOPHENECARBONITRILE(4651-92-7)
• EPA Substance Registry System: 2-AMINO-4-ETHYL-5-METHYL-3-THIOPHENECARBONITRILE(4651-92-7)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4651-92-7(Hazardous Substances Data)

Usage

Physical State

Yellowish, crystalline solid

Functional Groups

Amino group ( -\textNH2 )
Ethyl group ( -\textC2\textH5 )
Methyl group ( -\textCH3 )
Thiophene ring
Nitrile group ( -\textCN )

Applications

Intermediate in pharmaceutical synthesis
Intermediate in agrochemical synthesis
Building block for complex organic molecules

Utility

Reacts with other compounds to form complex organic molecules

Potential Applications

Medicinal chemistry
Material science

InChI:InChI=1/C8H10N2S/c1-3-6-5(2)11-8(10)7(6)4-9/h3,10H2,1-2H3

Upstream product

• 96-22-0 pentan-3-one 
• 109-77-3 malononitrile 

Downstream Products

• 439692-90-7 4-chloro-5-ethyl-6-methylthiopheno[2,3-d]pyrimidine 
• 439692-89-4 5-ethyl-6-methylthieno[2,3-d]pyrimidin-4(3H)-one 

Relevant articles and documents

Facile pathway for synthesis of two efficient catalysts for preparation of 2-aminothiophenes and tetrahydrobenzo[b]pyrans

Abstract: We report here a new magnetically recyclable catalyst consisting of iron-substituted Keggin-type heteropolyacid (HPA) grafted on modified Fe3O4 nanoparticles. The synthesized hybrid nanomaterial exhibited the excellent catalytic efficiency in condensation reaction for the preparation of tetrahydrobenzo[b]pyrans under solvent-free conditions as well as in the synthesis of 2-aminothiophenes via Gewald reaction. It must be noted that, HPA supported magnetite nanoparticles catalyzed the preparation of tetrahydrobenzo[b]pyrans, whereas for Gewald reaction amine-functionalized magnetite nanoparticles acted as a catalyst. Different characterization techniques such as Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used to characterize the hybrid nanomaterial. The reusability of catalyst was affirmed by using in consecutive runs for five times. Performance of prepared catalyst was compared with the various previously reported catalysts; the newly synthesized catalysts found to be most efficient with regard to reaction time, yield and ease of catalyst separation. Graphical Abstract: [Figure not available: see fulltext.].

Thieno [2, 3-d] pyrimidine compound, preparation method thereof and application thereof

The invention relates to the field of organic synthesis and discloses a thieno [2, 3-d] pyrimidine compound and an application thereof. The structure of the thieno [2, 3-d] pyrimidine compound is shown in a formula (1), wherein R1 and R2 independently rep

Synthesis, structural properties, and pharmacological evaluation of 2-(acylamino)thiophene-3-carboxamides and analogues thereof

We have previously reported the synthesis and the pharmacological characterization of a family of methyl 2-(acylamino)thiophene-3-carboxylates as GABAB positive allosteric modulators active both in vitro and in vivo. In the present work, we des