4652-24-8

Basic information

• Product Name: 2H-1,4-Benzothiazin-3(4H)-one, 2-(4-chlorophenyl)-
• CAS NO: 4652-24-8
• Molecular Formula: C14H10ClNOS
• Molecular Weight: 275.759
• Mol File: 4652-24-8.mol

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Benzothiazin-3(4H)-one, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzothiazin-3(4H)-one, 2-(4-chlorophenyl)-(4652-24-8)
• EPA Substance Registry System: 2H-1,4-Benzothiazin-3(4H)-one, 2-(4-chlorophenyl)-(4652-24-8)

Safety Data

• Hazardous Substances Data: 4652-24-8(Hazardous Substances Data)

Upstream product

• 33512-03-7 3-(4-chlorophenyl)oxirane-2,2-dicarbonitrile 
• 137-07-5 2-amino-benzenethiol 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 1141-88-4 2-Aminophenyl disulfide 

Relevant articles and documents

Regio-controlled synthesis of 1, 4-benzothiazinones

Regio-controlled cyclization of gem-dicyanoepoxides with 2-aminothiophenol and its hydrochloride to form 1,4-benzothiazine-2-one or 3-one is described. The cyclization is highly regioselective and the reaction of the epoxides with 2-aminothiophenol under neutral reaction condition gave 1,4-benzothiazine-2-one as a sole cyclized product, whereas that with hydrochloride of 2-aminothiophenol afforded 1,4-benzothiazine-3-one predominantly. The regioselectivity resulted from the reaction condition is discussed. The Japan Institute of Heterocyclic Chemistry.

A Convenient and General Synthesis of 2-Aryl- and 2-Pyridyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazines

The reaction of bis(2-aminophenyl) disulphide 1 with methyl or ethyl aryl- or pyridylacetates and sodium hydride gives the title compounds in good yield and high purity.The reaction is general, the starting materials easily available and the workup is simple and rapid.