465540-80-1

Basic information

• Product Name: 9-chloro-6-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indol-8(10H)-one
• CAS NO: 465540-80-1
• Molecular Formula: C₂₀H₁₆ClNO₂
• Molecular Weight: 337.7995
• Mol File: 465540-80-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 479.9°C at 760 mmHg
• Flash Point: 244°C
• Density: 1.39g/cm³
• Vapor Pressure: 5.1E-10mmHg at 25°C
• Refractive Index: 1.702
• CAS DataBase Reference: 9-chloro-6-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indol-8(10H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-chloro-6-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indol-8(10H)-one(465540-80-1)
• EPA Substance Registry System: 9-chloro-6-hydroxy-10,10-dimethyl-7-phenylpyrido[1,2-a]indol-8(10H)-one(465540-80-1)

Safety Data

• Hazardous Substances Data: 465540-80-1(Hazardous Substances Data)

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 1640-39-7 2,3,3-trimethylindoleniune 
• 274691-31-5 8-hydroxy-10,10-dimethyl-7-phenyl-10H-pyrido[1,2-a]indol-6-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 465540-76-5 7,9-dichloro-10,10-dimethyl-7-phenyl-10H-pyrido[1,2-a]indole-6,8(7H)-dione 

Relevant articles and documents

Synthesis and reactions of 10,10-dimethyl-10H-pyrido[1,2-a]indol-6-ones

Cyclocondensation of 2,3,3-trimethyl-3H-indoles 2 with malonates 3 gives 8-hydroxy-10,10-dimethyl-10H-pyrido[1,2-alindol-6-ones 4, which were halogenated in position 7, 8 and 9 with sulfuryl chloride, bromine or phosphoroxychloride to give the corresponding halo-10,10-dimethyl-10H-pyrido[1,2-a]indoles 5, 6, 7 and 8. Amination affords the 8-amino-10,10-dimethyl-10H-pyrido[1,2-a]indol-6-one 9. Nitration gives either the 10,10-dimethyl-7-nitro-10H-pyrido[1,2-a]indoles 10 or 10,10-dimethyl-7-hydroxy-10H-pyrido[1,2-a]indoles 11, depending on the conditions.