Basic information

Product Name: NERIIFOLIN
Synonyms: NERIIFOLIN;digitoxigenin+thevetose;xy)-14-hydroxy-;(3-beta,5-beta)-3-[(6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide;(5beta)-3beta-[(6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide;14-Hydroxy-5β-card-20(22)-enolide 3-(6-deoxy-3-O-methyl-α-L-glucopyranoside), 3-([6-Deoxy-3-O-methyl-α-L-glucopyranosyl]oxy)-14-hydroxy-5β-card-20(22)-enolide];(17R)-3β-(3-O-Methyl-6-deoxy-α-L-glucopyranosyloxy)-14-hydroxy-5β,14β-carda-20(22)-enolide;17α-Neriifolin
CAS NO:466-07-9
Molecular Formula: C₃₀H₄₆O₈
Molecular Weight: 534.68
EINECS: 207-372-5
Product Categories: N/A
Mol File: 466-07-9.mol

Chemical Properties

Melting Point: 218-225°C
Boiling Point: 700.1°Cat760mmHg
Flash Point: 224.9°C
Appearance: /
Density: 1.27g/cm³
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.581
Storage Temp.: 2-8°C
Solubility: Chloroform(Slightly), DMSO(Slightly), Methanol (Slightly), Water (Slightly)
CAS DataBase Reference: NERIIFOLIN(CAS DataBase Reference)
NIST Chemistry Reference: NERIIFOLIN(466-07-9)
EPA Substance Registry System: NERIIFOLIN(466-07-9)

Safety Data

Hazard Codes: T+
Statements: 26/27/28
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: FH4906100
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 466-07-9(Hazardous Substances Data)

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466-07-9 Usage

Uses

Used in Pharmaceutical Industry:
NERIIFOLIN is used as a candidate for the treatment of hepatocellular carcinoma, a type of liver cancer. Its chemopreventive and therapeutic potential is attributed to its ability to modulate various cellular signaling pathways, leading to the inhibition of tumor growth and progression.
Additionally, NERIIFOLIN is used as an inhibitor of hERG channel trafficking. The hERG (human Ether-à-go-go Related Gene) channel plays a crucial role in the repolarization of cardiac action potentials. Inhibition of hERG channel trafficking can help prevent the development of long QT syndrome, a heart condition characterized by abnormal heart rhythms and a risk of sudden death.

Check Digit Verification of cas no

The CAS Registry Mumber 466-07-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 466-07:
(5*4)+(4*6)+(3*6)+(2*0)+(1*7)=69
69 % 10 = 9
So 466-07-9 is a valid CAS Registry Number.

InChI:InChI=1/C30H46O8/c1-16-24(32)26(35-4)25(33)27(37-16)38-19-7-10-28(2)18(14-19)5-6-22-21(28)8-11-29(3)20(9-12-30(22,29)34)17-13-23(31)36-15-17/h13,16,18-22,24-27,32-34H,5-12,14-15H2,1-4H3/t16?,18-,19-,20-,21?,22?,24-,25?,26?,27+,28+,29-,30+/m1/s1

466-07-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	Neriifolin

1.2 Other means of identification

Product number	-
Other names	NERIIFOLIN

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:466-07-9 SDS

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