466-22-8Relevant academic research and scientific papers
AN UNUSUAL OXIDATION OF AN N-CH3 GROUP TO AN N-CHO GROUP BY OSMIUM TETROXIDE
Pelletier, S. William,Desai, Haridutt K.,Finer-Moore, Janet,Mody, Naresh V.
, p. 4229 - 4232 (1982)
Treatment of pyrodelphinine (1) with osmium tetroxide afforded a mixture of the cis-hydroxylation product 2 and an unexpected product 3 in the ratio of 4:1, respectively.Similarly, oxidation of delphinine (5) afforded α-oxodelphinine (6; 75percent) and oxidation of mesaconitine (8) furnished oxonitine (9; 92percent).Thus a very selective oxidation of the N-methyl group of delphinine and mesaconitine is effected by osmium tetroxide.
