4664-27-1

Basic information

• Product Name: (4-METHYLPYRIDIN-3-YL)METHANOL
• Synonyms: (4-METHYLPYRIDIN-3-YL)METHANOL;NSC30040;(4-methyl-3-pyridyl)methanol;4-Methyl-3-PyridineMethanol;3-HydroxyMethyl-4-Methylpyridine;4-Picoline-3-methanol
• CAS NO: 4664-27-1
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15246
• Product Categories: Hydroxymethyl's;Pyridines
• Mol File: 4664-27-1.mol

Chemical Properties

• Melting Point: 44-46℃
• Boiling Point: 125-127℃ (1.5-2.0 Torr)
• Flash Point: 113.2 °C
• Appearance: /
• Density: 1.092 g/cm³
• Vapor Pressure: 0.00515mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.71±0.10(Predicted)
• CAS DataBase Reference: (4-METHYLPYRIDIN-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHYLPYRIDIN-3-YL)METHANOL(4664-27-1)
• EPA Substance Registry System: (4-METHYLPYRIDIN-3-YL)METHANOL(4664-27-1)

Safety Data

• Hazardous Substances Data: 4664-27-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-METHYLPYRIDIN-3-YL)METHANOL is used as an intermediate in the synthesis of anti-inflammatory medications, contributing to the development of drugs that help manage inflammation and related conditions.
Used in Agrochemical Industry:
In the agrochemical sector, (4-METHYLPYRIDIN-3-YL)METHANOL is utilized as a precursor in the production of various agrochemicals, supporting agricultural practices by providing essential compounds for crop protection and enhancement.
Used in Specialty Chemicals Production:
(4-METHYLPYRIDIN-3-YL)METHANOL is employed as a building block in the creation of specialty chemicals, which are often used in specific applications due to their unique properties, such as in the formulation of high-performance materials or in niche industrial processes.
Used in Flavors Industry:
(4-METHYLPYRIDIN-3-YL)METHANOL is also used in the flavors industry, where its mild, sweet odor is harnessed to create or enhance the scent and taste profiles of various consumer products, such as food and beverages or fragrances.

InChI:InChI=1/C7H9NO/c1-6-2-3-8-4-7(6)5-9/h2-4,9H,5H2,1H3

Upstream product

• 3222-50-2 4-methylnicotinic acid 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 51227-28-2 4-methylnicotinaldehyde 
• 33402-75-4 4-methylnicotinic acid methyl ester 

Downstream Products

• 45658-41-1 3-Chloromethyl-4-methyl-pyridine 
• 604806-52-2 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine 1-oxide 
• 524775-30-2 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine 
• 604806-82-8 1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol 
• 604806-63-5 [4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-methanol 
• 604806-79-3 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridine-3-carbaldehyde 
• 524775-39-1 2-(4-{1-(3,4-bis-difluoromethoxy-phenyl)-2-[3-(1-hydroxy-ethyl)-1-oxy-pyridin-4-yl]-ethyl}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol 

Relevant articles and documents

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

Substituted 4-(2,2-Diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor that is well absorbed and that presents a shorter half-life than L-791,943 in a variety of animal species. The efficacy of L-826,141 is also demonstrated in different in vivo models.

The synthesis of Nauclea indole-pyridine alkaloids. 3,4-Disubstituted and 3,4,5-trisubstituted pyridines as synthetic intermediates; a total synthesis of (+/-)-decarbomethoxy-3α- and -3β-nauclechine

Synthetic routes to a number of 3,4-disubstituted and 3,4,5-trisubstituted pyridines have been explored.These pyridines, designed to be used in the synthesis of Nauclea indole-pyridine alkaloids, are potentially useful intermediates in a number of syntheses.Particular attention has been paid to more highly substituted derivatives of 4-pyridineacetic acid, and the experimental limitations associated with their synthesis and use in subsequent reactions such as the Bischler-Napieralski cyclization have been described and explained.A synthesis of decarbomethoxynauclechine from 4-methylnicotinaldehyde avoiding these difficulties was then de signed and executed.Both diastereoisomers, (+/-)-decarbomethoxy-3α-nauclechine and (+/-)-decarbomethoxy-3β-nauclechine, were obtained; the structure and stereochemistry of each was rigorously established, but it was not possible to demonstrate which corresponded to the natural alkaloid, decarbomethoxynauclechine, reported previously.