4664-27-1

Basic information

• Product Name: (4-METHYLPYRIDIN-3-YL)METHANOL
• Synonyms: (4-METHYLPYRIDIN-3-YL)METHANOL;NSC30040;(4-methyl-3-pyridyl)methanol;4-Methyl-3-PyridineMethanol;3-HydroxyMethyl-4-Methylpyridine;4-Picoline-3-methanol
• CAS NO: 4664-27-1
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15246
• Product Categories: Hydroxymethyl's;Pyridines
• Mol File: 4664-27-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 44-46℃
• Boiling Point: 125-127℃ (1.5-2.0 Torr)
• Flash Point: 113.2 °C
• Appearance: /
• Density: 1.092 g/cm³
• Vapor Pressure: 0.00515mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.71±0.10(Predicted)
• CAS DataBase Reference: (4-METHYLPYRIDIN-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHYLPYRIDIN-3-YL)METHANOL(4664-27-1)
• EPA Substance Registry System: (4-METHYLPYRIDIN-3-YL)METHANOL(4664-27-1)

Safety Data

• Hazardous Substances Data: 4664-27-1(Hazardous Substances Data)

Usage

General Description

(4-METHYLPYRIDIN-3-YL)METHANOL, also known as 3-(4-pyridyl)propanol, is a chemical compound with the molecular formula C8H11NO. It is a clear, colorless liquid that is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of specialty chemicals and flavors. (4-METHYLPYRIDIN-3-YL)METHANOL is known for its mild, sweet odor and is considered to be a relatively stable and non-reactive compound. Its main applications include in the manufacturing of anti-inflammatory medications, synthetic antioxidants, and various other organic compounds. Overall, it is an important chemical in the synthesis of a wide range of pharmaceutical and agrochemical products.

InChI:InChI=1/C7H9NO/c1-6-2-3-8-4-7(6)5-9/h2-4,9H,5H2,1H3

Upstream product

• 3222-50-2 4-methylnicotinic acid 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 51227-28-2 4-methylnicotinaldehyde 
• 33402-75-4 4-methylnicotinic acid methyl ester 

Downstream Products

• 45658-41-1 3-Chloromethyl-4-methyl-pyridine 
• 604806-52-2 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine 1-oxide 
• 524775-30-2 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3-triisopropylsilanyloxymethyl-pyridine 
• 604806-82-8 1-[4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-ethanol 
• 604806-63-5 [4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridin-3-yl]-methanol 
• 604806-79-3 4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-pyridine-3-carbaldehyde 
• 524775-39-1 2-(4-{1-(3,4-bis-difluoromethoxy-phenyl)-2-[3-(1-hydroxy-ethyl)-1-oxy-pyridin-4-yl]-ethyl}-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol 

Relevant articles and documents

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

The synthesis of Nauclea indole-pyridine alkaloids. 3,4-Disubstituted and 3,4,5-trisubstituted pyridines as synthetic intermediates; a total synthesis of (+/-)-decarbomethoxy-3α- and -3β-nauclechine

Synthetic routes to a number of 3,4-disubstituted and 3,4,5-trisubstituted pyridines have been explored.These pyridines, designed to be used in the synthesis of Nauclea indole-pyridine alkaloids, are potentially useful intermediates in a number of syntheses.Particular attention has been paid to more highly substituted derivatives of 4-pyridineacetic acid, and the experimental limitations associated with their synthesis and use in subsequent reactions such as the Bischler-Napieralski cyclization have been described and explained.A synthesis of decarbomethoxynauclechine from 4-methylnicotinaldehyde avoiding these difficulties was then de signed and executed.Both diastereoisomers, (+/-)-decarbomethoxy-3α-nauclechine and (+/-)-decarbomethoxy-3β-nauclechine, were obtained; the structure and stereochemistry of each was rigorously established, but it was not possible to demonstrate which corresponded to the natural alkaloid, decarbomethoxynauclechine, reported previously.