4666-78-8Relevant academic research and scientific papers
KRAS G12C INHIBITORS
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Page/Page column 128, (2021/06/22)
The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.
Photochemistry of Hydrogen Bromide-Acetylene Complexes in Solid Krypton
Abrash, Samuel A.,Carr, Celia M.,McMahon, Michael T.,Zehner, Robert W.
, p. 11909 - 11917 (2007/10/02)
Hydrogen-bonded complexes between HBr and acetylene in inert gas matrices were subjected to medium-pressure Hg lamp photolysis at 12 K.For HBr-acetylene, the major product was bromoacetylene, while vinyl bromide was present in trace amounts.When HBr-perdeuterioacetylene and DBr-acetylene complexes were photolyzed, bromoacetylene, deuteriobromoacetylene, and the hydrogen exchange product, DBr(HBr)-C2HD, were the primary products.Partially deuterated vinyl bromides were present in trace amounts.In HBr-perdeuterioacetylene, the only isomer observed was cis-CDBr=CHD.In DBr-acetylene, both cis- and trans-CHBr=CHD were observed.In neither experiment was the 1,1-addition product formed.The results are interpreted in terms of the supramolecule model of complex photochemistry put forth by Abrash and Pimentel.
