466634-79-7

Basic information

• Product Name: 4-pyrimidin-2-ylbenzoic acid methyl ester
• Synonyms: 4-pyrimidin-2-ylbenzoic acid methyl ester
• CAS NO: 466634-79-7
• Molecular Weight: 214.224
• Mol File: 466634-79-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-pyrimidin-2-ylbenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-pyrimidin-2-ylbenzoic acid methyl ester(466634-79-7)
• EPA Substance Registry System: 4-pyrimidin-2-ylbenzoic acid methyl ester(466634-79-7)

Safety Data

• Hazardous Substances Data: 466634-79-7(Hazardous Substances Data)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 619-44-3 methyl 4-iodobenzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 4595-60-2 2-bromopyrimidine 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 

Downstream Products

• 199678-12-1 4-(pyrimidine-2-yl)benzoic acid 

Relevant articles and documents

KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

Syntheses of substituted pyridines, quinolines and diazines via palladium-catalyzed cross-coupling of aryl Grignard reagents

The palladium-catalyzed cross-coupling reactions between arylmagnesium halides (phenylmagnesium chloride, mesitylmagnesium bromide, 4-(methoxycarbonyl)phenylmagnesium chloride and 4-cyanophenylmagnesium chloride) and halopyridines allowed the synthesis of substituted pyridines. Owing to the remarkably mild conditions used (often below 0°C), the reaction could be extended to the use of functionalized halopyridines, haloquinolines and halodiazines.