466651-76-3

Upstream product

• 137049-21-9 (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 466651-68-3 (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-[((R)-4-ethoxycarbonyl)thiazolidin-2-yl]-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 

Downstream Products

• 466652-06-2 (4R,5S,6S)-3-[(3S,5S)-5-((S)-4-Ethoxycarbonyl-[1,3]thiazinan-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 466652-07-3 (4R,5S,6S)-3-[(3S,5S)-5-((S)-4-Carbamoyl-[1,3]thiazinan-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 466651-87-6 (S)-2-[(2S,4S)-4-Mercapto-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-2-yl]-[1,3]thiazinane-4-carboxylic acid ethyl ester 
• 466651-88-7 (2S,4S)-2-((S)-4-Carbamoyl-[1,3]thiazinan-2-yl)-4-mercapto-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 466651-77-4 2-[(4R,2S)-4-(tert-butyldimethylsilanyloxy)-1-(p-nitrobenzyloxycarbonyl)pyrrolidin-2-yl]-[1,3]thiazinane-4(R)-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolidinopyrrolidin-3-ylthio)carbapenems and related compounds

The synthesis of a new series of 1β-methylcarbapenems containing the substituted thiazolidinopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the thiazolidine ring was investigated. A particular compound (18c) having a 2-amide substituted thiazolidine moiety showed the most potent antibacterial activity.