466652-16-4

Basic information

• Product Name: (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-[(3S,5S)-5-(3-methanesulfonyl-thiazolidin-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
• CAS NO: 466652-16-4
• Molecular Weight: 791.881
• Mol File: 466652-16-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-[(3S,5S)-5-(3-methanesulfonyl-thiazolidin-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-[(3S,5S)-5-(3-methanesulfonyl-thiazolidin-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester(466652-16-4)
• EPA Substance Registry System: (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-[(3S,5S)-5-(3-methanesulfonyl-thiazolidin-2-yl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester(466652-16-4)

Safety Data

• Hazardous Substances Data: 466652-16-4(Hazardous Substances Data)

Upstream product

• 466651-92-3 (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-(3-methanesulfonylthiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 466651-78-5 (4R,2S)-4-(tert-butyldimethylsilanyloxy)-2-(thiazolidin-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 137049-21-9 (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 93711-81-0 (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 466651-93-4 (2S,4S)-4-Mercapto-2-(3-methanesulfonyl-thiazolidin-2-yl)-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolidinopyrrolidin-3-ylthio)carbapenems and related compounds

The synthesis of a new series of 1β-methylcarbapenems containing the substituted thiazolidinopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the thiazolidine ring was investigated. A particular compound (18c) having a 2-amide substituted thiazolidine moiety showed the most potent antibacterial activity.