466671-90-9Relevant academic research and scientific papers
New approach to the stereoselective synthesis of metalated dienes via an isomerization-elimination sequence
Chinkov, Nicka,Majumdar, Swapan,Marek, Ilan
, p. 10282 - 10283 (2002)
Treatment of Cp2ZrBu2 with enol ether containing a remote double bond lead to conjugated metalated diene as single isomer via a tandem isomerization-elimination sequence. 2-Arylsulfonyl 1,3-dienes can also be used as a source of dienyl zirconocene derivatives, and the stereochemistry of the diene is dependent on the transmetalation reaction. Copyright
Stereoselective Preparation of Dienyl Zirconocene Complexes via a Tandem Allylic C-H Bond Activation-Elimination Sequence
Chinkov, Nicka,Majumdar, Swapan,Marek, Ilan
, p. 13258 - 13264 (2007/10/03)
Several dienyl zirconocene derivatives were easily prepared, as unique geometrical isomers, from simple non-conjugated unsaturated enol ethers with (1-butene)ZrCp2 complexes. This new methodology is based on a tandem allylic C-H bond activation-elimination sequence and the mechanism has been mapped out by deuterium labeling experiments. The stereochemical outcome of this process was determined by addition of several electrophiles. Moreover, when the organometallic derivative is vinylic as well as allylic such as in 44-47Zr, an unexpected reversal of the stereochemistry has been found during the zirconium to copper transmetalation step.
