466686-79-3 Usage
Uses
Used in Pharmaceutical Industry:
2-Thiazolecarboxaldehyde, 4-chlorois used as a key intermediate in the synthesis of substituted Triazolopiperazine derivatives. These derivatives have been found to possess significant biological activities, particularly as PARP (Poly ADP-ribose polymerase) inhibitors.
PARP inhibitors are a class of drugs that have shown promise in the treatment of various types of cancer by targeting the DNA repair mechanism in cancer cells, leading to their death. The use of 2-Thiazolecarboxaldehyde, 4-chloroin the preparation of these inhibitors highlights its importance in the development of novel anticancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 466686-79-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,6,6,8 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 466686-79:
(8*4)+(7*6)+(6*6)+(5*6)+(4*8)+(3*6)+(2*7)+(1*9)=213
213 % 10 = 3
So 466686-79-3 is a valid CAS Registry Number.
466686-79-3Relevant academic research and scientific papers
COMPOUNDS AS PROTEIN KINASE INHIBITORS
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Paragraph 218; 262; 265-266, (2021/11/26)
Provided are certain PI3K inhibitors, pharmaceutical compositions thereof, and methods of use thereof.
TRICYCLIC COMPOUNDS
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Paragraph 1899; 1900, (2014/06/25)
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
TRICYCLIC COMPOUNDS
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Paragraph 0883; 0889; 0890, (2014/06/25)
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
