4667-83-8

Basic information

• Product Name: 2-(furan-2-ylmethyl)isoindoline-1,3-dione
• Synonyms: 2-(furan-2-ylmethyl)isoindoline-1,3-dione;2-(furan-2-ylmethyl)isoindole-1,3-dione
• CAS NO: 4667-83-8
• Molecular Formula: C₁₃H₉NO₃
• Molecular Weight: 227.21546
• Mol File: 4667-83-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(furan-2-ylmethyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(furan-2-ylmethyl)isoindoline-1,3-dione(4667-83-8)
• EPA Substance Registry System: 2-(furan-2-ylmethyl)isoindoline-1,3-dione(4667-83-8)

Safety Data

• Hazardous Substances Data: 4667-83-8(Hazardous Substances Data)

Usage

General Description

2-(furan-2-ylmethyl)isoindoline-1,3-dione, also known as isoindoline-1,3-dione, is a complex organic compound with a molecular formula of C14H9NO3. It is a heterocyclic compound containing a furan ring and an isoindoline-1,3-dione ring, and is commonly used in organic synthesis and pharmaceutical research. The compound has potential applications in the development of new drugs and the production of organic materials due to its unique structural and chemical properties. Additionally, it has been studied for its antioxidant and anti-inflammatory properties, making it a promising candidate for further research into its potential medical applications.

Upstream product

• 85-44-9 phthalic anhydride 
• 617-89-0 furan-2-ylmethanamine 

Downstream Products

• 5451-09-2 5-aminolevulinic acid hydrochloride 

Relevant articles and documents

Preparation method of 5 -aminolevulinic acid hydrochloride intermediate (by machine translation)

The invention relates to a preparation method of 5 -aminolevulinic acid hydrochloride intermediate, which belongs to the field of pharmaceutical compound synthesis and provides a 5 -aminolevulinic acid hydrochloride intermediate preparation method which comprises the following technical points: (a), (1) or (2) compound in reaction solvent a, oxidizing agent a, compound of formula (5); or process b) wherein the compound of formula (6) or formula (3 4) is obtained under the action of a reaction solvent b and an oxidizing agent b 6. The compound of formula (6) is then purified to give 5 -aminolevulinic acid hydrochloride by an acidic hydrolysis deprotecting group, or a direct acidic hydrolysis deprotecting group. The environment-friendly oxidation reagent is adopted, the quality requirement of high-quality medicine raw materials can be met at the same time, the production efficiency can be improved, and the requirement of industrial large-scale production can be met. (by machine translation)

Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement

An alkoxide-catalyzed hydrosilylation of cyclic imides to isoquinolines was realized via tandem reduction and rearrangement. Using TMSOK as the catalyst and (EtO)2MeSiH as the reductant, a series of cyclic imides containing different functional groups were reduced to the corresponding 3-aryl isoquinolines in moderate to good yields. The scenario of the reaction pathway was supposed to involve the reduction of imides to ω-hydroxylactams, which underwent rearrangement in the presence of a base catalyst, and then the carbonyl reduction, followed by siloxy elimination.

Tandem Mannich/Diels-Alder reactions for the synthesis of indole compound libraries

A tandem Mannich/Diels-Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.