4668-08-0

Basic information

• Product Name: 2,3,4-TRIMETHOXY-BETA-NITROSTYRENE, >95%
• Synonyms: 2,3,4-TRIMETHOXY-BETA-NITROSTYRENE, >95%
• CAS NO: 4668-08-0
• Molecular Formula: C₁₁H₁₃NO₅
• Molecular Weight: 0
• Mol File: 4668-08-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 370.3°Cat760mmHg
• Flash Point: 163.9°C
• Appearance: /
• Density: 1.203g/cm³
• Vapor Pressure: 2.38E-05mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 2,3,4-TRIMETHOXY-BETA-NITROSTYRENE, >95%(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIMETHOXY-BETA-NITROSTYRENE, >95%(4668-08-0)
• EPA Substance Registry System: 2,3,4-TRIMETHOXY-BETA-NITROSTYRENE, >95%(4668-08-0)

Safety Data

• Hazardous Substances Data: 4668-08-0(Hazardous Substances Data)

Usage

Purity

Over 95%

Chemical structure

Nitroalkene derivative with three methoxy groups

Usage

Synthesis of various pharmaceuticals and fine chemicals

Importance

Key intermediate in the synthesis of biologically active molecules

Biological activity

Potent

Pharmacological applications

Being studied for potential applications

Suitability

Suitable for research and development in the pharmaceutical and chemical industries.

InChI:InChI=1/C11H13NO5/c1-15-9-5-4-8(6-7-12(13)14)10(16-2)11(9)17-3/h4-7H,1-3H3/b7-6+

Upstream product

• 75-52-5 nitromethane 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 3937-16-4 2-(2,3,4-trimethoxyphenyl)ethylamine 

Relevant articles and documents

Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σ2R/TMEM97 ligands

Sigma-2 receptor (σ2R/TMEM97) has been implicated to play important roles in multiple cellular dysfunctions, such as cell neoplastic proliferation, neuro-inflammation, neurodegeneration, etc. Selective σ2 ligands are believed to be promising pharmacological tools to regulate or diagnose various disorders. As an ongoing effort of discovery of new and selective σ2 ligands, we have synthesized a series of tetrahydroisoquinolino-2-alkyl phenone analogs and identified that 10 of them have moderate to potent affinity and selectivity for σ2R/TMEM97. Especially, 4 analogs showed Ki values ranging from 0.38 to 5.1 nM for σ2R/TMEM97 with no or low affinity for sigma-1 receptor (σ1R). Functional assays indicated that these 4 most potent analogs had no effects on intracellular calcium concentration and were classified as putative σ2R/TMEM97 antagonists according to current understanding. The σ2R/TMEM97 has been suggested to play important roles in the central nervous system. Based on published pharmacological and clinical results from several regarded σ2R/TMEM97 antagonists, these analogs may potentially be useful for the treatment of various neurodegenerative diseases.

ZrCl4-mediated synthesis of 1,2,3-triazoles from vinyl nitrates and their biological evaluation

A ZrCl4-mediated simple method for the conversion of vinyl nitrates to 1,2,3-triazoles in excellent yields is developed. The obtained new triazoles were evaluated for their antimicrobial activity.

1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF

Compounds of general formula (I) wherein D, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.