4672-25-7Relevant academic research and scientific papers
Rapid one-pot synthesis of alkane-α ω, diylbisphosphonic acids from dihalogenoalkanes under microwave irradiation
Villemin, Didier,Moreau, Bernard,Kaid, M'Hamed,Didi, Mohamed Amine
experimental part, p. 1583 - 1586 (2010/10/01)
A one-pot, two-step synthesis of alkylenebisphosphonic acids from dihalogenoalkanes was performed under microwave irradiation. The reaction is very rapid and convenient for the synthesis of small samples of alkylenebisphosphonic acids. Copyright Taylor & Francis Group, LLC.
Highly potent bisphosphonate ligands for phosphoglycerate kinase
Jakeman, David L.,Ivory, Andrew J.,Williamson, Michael P.,Blackburn, G. Michael
, p. 4439 - 4452 (2007/10/03)
We have synthesized a series of novel analogs of 1,3-bisphospho-D- glyceric acid, 1,3-BPG, and evaluated their binding to phosphoglycerate kinase, PGK (EC 2.7.2.3). Nonscissile methanephosphonic acids replace the two phosphate monoesters of 1,3-BPG and lead to several stable, tight-binding mimics of this intermediate species in glycolysis. Multiple fluorine substitution for hydrogen in the α-methylene groups of the phosphonic acid 1,3-BPG analogs markedly improves their binding to PGK as determined by NMR analysis. The best ligands bind some 50-100 times more strongly than does the substrate 3-phospho-D-glyceric acid and show a requirement for pK(a)3 to be generally below 6.0, while the presence of a β-carbonyl group seems to be of secondary importance.
