467221-61-0

Basic information

• Product Name: H-[L-(α-Me)Val]2-Ot-Bu
• Synonyms: H-[L-(α-Me)Val]2-Ot-Bu
• CAS NO: 467221-61-0
• Molecular Weight: 300.442
• Mol File: 467221-61-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-[L-(α-Me)Val]2-Ot-Bu(CAS DataBase Reference)
• NIST Chemistry Reference: H-[L-(α-Me)Val]2-Ot-Bu(467221-61-0)
• EPA Substance Registry System: H-[L-(α-Me)Val]2-Ot-Bu(467221-61-0)

Safety Data

• Hazardous Substances Data: 467221-61-0(Hazardous Substances Data)

Upstream product

• 4378-19-2 (S)-α-Methylvaline 

Downstream Products

• 182688-24-0 Z-[L-(αMe)Val]5-OtBu 
• 182688-23-9 (S)-2-{(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-2,3-dimethyl-butyrylamino)-2,3-dimethyl-butyrylamino]-2,3-dimethyl-butyrylamino}-2,3-dimethyl-butyric acid tert-butyl ester 
• 182688-22-8 Z-[L-(αMe)Val]3-OtBu 

Relevant articles and documents

Amino acid bromides: Their N-protection and use in the synthesis of peptides with extremely difficult sequences

Nα-Protected α-amino acid bromides were easily generated in situ with 1-bromo-N,N-2-trimethyl-1-propenylamine from the corresponding amino acids under very mild conditions. o-Nbs and the azido moieties proved to be compatible with these overactivated halides and were successfully applied in difficult peptide bond formations. N-Deprotection methods and the total step-by-step solution synthesis of a peptide containing up to seven consecutive L-(αMe)Valine residues are also reported. The assembly of this homopeptide was achieved in a short time and in very high yields by the azido/bromide system in a single repetitive operation.