4673-45-4

Usage

Type of drug

Local anesthetic and antiarrhythmic medication

Mechanism of action

Blocks sodium channels in nerve cells, preventing pain signaling

Medical and dental procedures

To numb skin or mucous membranes

Antiarrhythmic treatment

To treat certain types of irregular heartbeats

Available forms

Creams, ointments, and solutions

Tolerance

Generally well-tolerated when used as directed

Side effects

Allergic reactions, skin irritation, and changes in heart rhythm

Precaution

Should be used with caution and under the supervision of a healthcare professional

InChI:InChI=1/C16H17NO/c1-18-16-9-7-15(8-10-16)13-17-12-11-14-5-3-2-4-6-14/h2-10,13H,11-12H2,1H3/b17-13+

Upstream product

• 1852-17-1 3,4,5,6-tetrahydropyrimidin-2(1H)-one 
• 542-69-8 1-iodo-butane 
• 4697-92-1 N,N'-dibutyl-propane-1,3-diamine 

Relevant academic research and scientific papers

Process for producing cyclic ureas

A process for producing a cyclic urea is provided. The process comprises reacting a diamine expressed by the formula (II) wherein R represents hydrogen atom or a lower alkyl group and R' represent dimethylene group, a lower alkyl group-substituted dimethylene group, trimethylene group, a lower alkyl group-substituted trimethylene group, tetramethylene group, a lower alkyl group-substituted tetramethylene group, but a case where R represents hydrogen atom and R' represent dimethylene group, a case where R represents hydrogen atom and R' represents a lower alkyl group-substituted dimethylene group and a case where R represent methyl group and R' represents dimethylene group are excluded, with phosgene in the presence of a dehydrochlorinating agent. In the process, the diamine is first converted to its hydrochloride, followed by reacting the hydrochloride with phosgene in water solvent while maintaining a pH of the reaction liquid in the range of 5.0 to 8.0 by said dehydrochlorinating agent to obtain a cyclic urea expressed by the formula (I) STR1 wherein R and R' are each as defined above.

Cyclic Urea and Thiourea Derivatives as Inducers of Murine Erythroleukemia Differentiation

A series of derivatives of tetramethylurea, a known inducer of the differentiation of Friend erythroleukemia cells, has been synthesized and tested for its capacity to induce erythroid maturation, as measured by the synthesis of hemoglobin.Cyclic urea and thiourea derivatives consisting of five-, six-, and seven-membered ring systems containing N-alkyl substituents were prepared.Most of these agents were relatively effective inducers of differentiation, with N-alkyl substitution appearing to be essential for maximum response.The most potent agents developed wereN,N'-dimethyl cyclic ureas.Exposure to concentrations of 2 to 4 mM of these derivatives resulted in more than 90percent of the cell population achieving a differentiated state.Under these conditions, the parent compound, tetramethylurea, was slightly less efficacious, causing differentiation of only 68percent of the population at its maximum effective level of 4 mM.