46739-05-3 Usage
Uses
Used in Pharmaceutical Industry:
2-(piperidin-1-ylmethyl)-1H-indole is used as a therapeutic agent for mental health disorders due to its agonistic action at the 5-HT1A serotonin receptor, which is implicated in mood regulation and anxiety reduction.
Used in Drug Abuse Treatment:
PMI is utilized as a potential treatment for drug abuse, leveraging its psychoactive properties to assist in managing withdrawal symptoms and potentially reducing cravings for substances of abuse.
Used in Cardiovascular Research:
2-(piperidin-1-ylmethyl)-1H-indole is employed in research settings to study its effects on cardiovascular functioning, given the role of serotonin in various physiological processes, including those related to the heart and blood vessels.
Check Digit Verification of cas no
The CAS Registry Mumber 46739-05-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,6,7,3 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 46739-05:
(7*4)+(6*6)+(5*7)+(4*3)+(3*9)+(2*0)+(1*5)=143
143 % 10 = 3
So 46739-05-3 is a valid CAS Registry Number.
46739-05-3Relevant academic research and scientific papers
Palladium-catalyzed synthesis of 2-(aminomethyl)indoles from ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate
Ambrogio, Ilaria,Cacchi, Sandro,Fabrizi, Giancarlo
, p. 2083 - 2086 (2007/10/03)
The palladium-catalyzed reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1- propargyl carbonate with piperazines in the presence of Pd(PPh3) 4 in THF at 80 °C affords 2-(piperazin-1-ylmethyl)indoles in excellent yields. Good to excellent yields are also obtained with other secondary amines.
