467421-88-1

Basic information

• Product Name: (E)-4-(3-methoxyphenyl)-1,1-bis(methylthio)-3-nitro-1,3-butadiene
• Synonyms: (E)-4-(3-methoxyphenyl)-1,1-bis(methylthio)-3-nitro-1,3-butadiene
• CAS NO: 467421-88-1
• Molecular Weight: 297.399
• Mol File: 467421-88-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-4-(3-methoxyphenyl)-1,1-bis(methylthio)-3-nitro-1,3-butadiene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(3-methoxyphenyl)-1,1-bis(methylthio)-3-nitro-1,3-butadiene(467421-88-1)
• EPA Substance Registry System: (E)-4-(3-methoxyphenyl)-1,1-bis(methylthio)-3-nitro-1,3-butadiene(467421-88-1)

Safety Data

• Hazardous Substances Data: 467421-88-1(Hazardous Substances Data)

Upstream product

• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 389838-05-5 (1E)-4,4-bis(methylthio)-2-nitro-1-pyrrolidino-1,3-butadiene 

Downstream Products

• 467422-01-1 3-hydroxyimino-4-(3-methoxyphenyl)-1,1-bis(methylthio)-1-butene 

Relevant articles and documents

Access to 3-arylmethyl-5-(methylthio)isoxazoles via an initial ring-opening of 2-methylthio-4-nitrothiophene

The reactions of 1,1-bis(methylthio)-3-nitro-4-pyrrolidino-1,3-butadiene (deriving from the initial ring-opening of 2-methylthio-4-nitrothiophene with pyrrolidine and silver nitrate in EtOH) with arylmagnesium bromides result in the chemoselective replacement of the pyrrolidino group with the aryl moiety of the Grignards. The 4-aryl-1,1-bis(methylthio)-3-nitro-1,3-butadienes thus obtained are the key intermediates for the effective synthesis, through the corresponding reduction products 4-aryl-3-hydroximino-1,1-bis(methylthio)-1-butenes, of the previously unknown 3-arylmethyl-5-(methylthio)isoxazoles.