467435-75-2

Usage

Uses

Used in Organic Synthesis:
2-Ethynylpyrrole-1-carboxylic Acid, t-Butyl Ester is used as a synthetic intermediate for the development of a wide range of organic compounds. Its unique chemical structure allows it to be a versatile building block in the synthesis of various molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Ethynylpyrrole-1-carboxylic Acid, t-Butyl Ester is used as a key component in the synthesis of novel drug candidates. Its incorporation into drug molecules can potentially enhance their pharmacological properties, such as potency, selectivity, and bioavailability, leading to the development of more effective therapeutic agents.
Used in Agrochemical Industry:
2-Ethynylpyrrole-1-carboxylic Acid, t-Butyl Ester also finds application in the agrochemical industry, where it is employed in the synthesis of new pesticides and other crop protection agents. Its unique chemical properties can contribute to the development of innovative products with improved performance and reduced environmental impact.
Used in Material Science:
In the field of material science, 2-Ethynylpyrrole-1-carboxylic Acid, t-Butyl Ester can be used as a component in the development of advanced materials with specific properties, such as conductivity, magnetism, or optical activity. Its incorporation into these materials can lead to the creation of novel materials with enhanced performance and applications in various industries.

Upstream product

• 117657-37-1 2-bromo-pyrrole-1-carboxylic acid tert-butyl ester 
• 467435-72-9 2-(trimethylsilylethynyl)pyrrole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 467435-77-4 2,7-bis-(1-tert-butoxycarbonylpyrrol-2-yl)ethynyl-1,8-naphthyridine 

Relevant academic research and scientific papers

2,7-Bis(1H-pyrrol-2-yl)ethynyl-1,8-naphthyridine: An Ultrasensitive Fluorescent Probe for Glucopyranoside

(Matrix Presented) A push-pull conjugated molecule, 2,7-bis(1H-pyrrol-2-yl)ethynyl-1,8-naphthyridine (BPN), has been designed to bind selectively with octyl glucopyranoside (OGU). The BPN/OGU quadruple hydrogen-bonding complex adopts a rigid BPN conformation in which the proton donor (d) and acceptor (a) relays (daad) are resonantly conjugated through the ethynyl bridge, inducing π-electron delocalization, i.e., a charge transfer effect. The excellent photophysical properties make BPN a highly sensitive probe for monitoring glucopyranoside to a detection limit of ～100 pM.

Fluorescent and Circular Dichroic Detection of Monosaccharides by Molecular Sensors: Bis[(Pyrrolyl)ethynyl]naphthyridine and Bis[(Indolyl)ethynyl]naphthyridine

The push-pull conjugated molecules 2,7-bis-(1H-pyrrol-2-yl)ethynyl-1,8-naphthyridine (BPN) and 2,7-bis(1H-indol-2-yl)ethynyl-1,8-naphthyridine (BIN) adopting daad relays of proton donors (d) and acceptors (a) form multiple hydrogen-bonding complexes with various monosaccharides that possess complementary adda sequences. Although the free BPN emits blue light at λmax = 475 nm in CH2Cl2, its complexation with octyl β -D-glucopyranoside gives green fluorescence at λmax = 535 nm. The excellent photophysical properties make BPN a highly sensitive probe for monitoring glucopyranoside to a detection limit of ～100 pM. On the other hand, the CD-silent BIN molecule binds with monosaccharides to form the CD-active multiple hydrogen-bonding complexes, which exhibit the remarkable chirality dependent helicities consistent with the prediction by the ab initio approaches. On the basis of the similar daad cleft and hence the binding property, the fluorescence and CD absorption methods in BPN and BIN, respectively, are complementary, which, in combination with computational molecular modeling, not only give a detailed insight into the structures of the receptor-saccharide complexes in solution, but also differentiate octyl β-D-glucopyranoside from its enantiomer and other monosaccharides.