467442-20-2 Usage
Uses
Used in Pharmaceutical Industry:
(S)-2-(tert-butoxycarbonylamino)-4,4-difluorobutanoic acid is used as a key intermediate in the development of new drugs. Its unique functional groups, including the fluorine atom and the tert-butoxycarbonylamino group, provide opportunities for the design and synthesis of novel pharmaceutical compounds with improved therapeutic properties.
Used in Organic Chemistry Research:
In the field of organic chemistry, (S)-2-(tert-butoxycarbonylamino)-4,4-difluorobutanoic acid serves as a versatile building block for the synthesis of various organic molecules. Its presence of fluorine and tert-butoxycarbonylamino groups allows for the exploration of new synthetic pathways and the development of innovative chemical reactions, contributing to the advancement of organic chemistry.
Used in Drug Synthesis:
(S)-2-(tert-butoxycarbonylamino)-4,4-difluorobutanoic acid is used as a chiral synthon in the synthesis of enantioselective drugs. Its specific enantiomeric form ensures that the resulting pharmaceutical compounds possess the desired stereochemistry, which is crucial for their biological activity and therapeutic efficacy.
Used in Medicinal Chemistry:
In medicinal chemistry, (S)-2-(tert-butoxycarbonylamino)-4,4-difluorobutanoic acid is employed as a structural motif in the design of new drug candidates. Its unique functional groups can be further modified or combined with other chemical moieties to create novel compounds with potential therapeutic applications.
Used in Biochemistry and Molecular Biology:
(S)-2-(tert-butoxycarbonylamino)-4,4-difluorobutanoic acid can be used as a probe or a tool in biochemical and molecular biology research. Its specific functional groups can be exploited to study enzyme mechanisms, protein-ligand interactions, and other biological processes, providing valuable insights into the molecular basis of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 467442-20-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,7,4,4 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 467442-20:
(8*4)+(7*6)+(6*7)+(5*4)+(4*4)+(3*2)+(2*2)+(1*0)=162
162 % 10 = 2
So 467442-20-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H15F2NO4/c1-9(2,3)16-8(15)12-5(7(13)14)4-6(10)11/h5-6H,4H2,1-3H3,(H,12,15)(H,13,14)/t5-/m0/s1
467442-20-2Relevant articles and documents
Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.
Lamar, Jason,Hu, Jingdan,Bueno, Ana Belen,Yang, Hsiu-Chiung,Guo, Deqi,Copp, James D,McGee, James,Gitter, Bruce,Timm, David,May, Patrick,McCarthy, James,Chen, Shu-Hui
, p. 239 - 243 (2004)
We describe herein the syntheses and evaluation of a series of C-termini pyridyl containing Phe*-Ala-based BACE inhibitors (5-19). In conjunction with four fixed residues at the P1 (Phe), P1' (Ala), P2' (Val), and P2' cap (Pyr.), rather detailed SAR modifications at P2 and P3 positions were pursued. The promising inhibitors emerging from this SAR investigation, 12 and 17 demonstrated very good enzyme potency (IC(50)=45 nM) and cellular activity (IC(50)=0.4 microM).
