467442-68-8Relevant academic research and scientific papers
Pyrimidinylpyrroloquinolones as highly potent and selective PDE5 inhibitors for treatment of erectile dysfunction
Sui, Zhihua,Guan, Jihua,Macielag, Mark J.,Jiang, Weiqin,Zhang, Suying,Qiu, Yuhong,Kraft, Patricia,Bhattacharjee, Sheela,John, T. Matthew,Haynes-Johnson, Donna,Clancy, Joanna
, p. 4094 - 4096 (2007/10/03)
A series of N-pyrimidinylpyrroloquinolones were discovered as extremely potent and selective PDE5 inhibitors. Representative compounds demonstrated in vivo efficacy in dog erectile dysfunction models and are orally bioavailable.
