46745-66-8

Usage

Uses

4-n-Octylstyrene (stabilized with TBC) is a useful research chemical.

InChI:InChI=1/C16H24/c1-3-5-6-7-8-9-10-16-13-11-15(4-2)12-14-16/h4,11-14H,2-3,5-10H2,1H3

Upstream product

• 10541-56-7 4-n-octylacetophenone 
• 2189-60-8 Octylbenzene 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 49763-66-8 4-octylbenzaldehyde 

Downstream Products

• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 876391-69-4 2-methylene-4-(4'-octylphenyl)butan-1-ol 
• 1430811-66-7 (S)-2-(4-octylphenethyl)oxirane-2-carboxaldehyde 
• 1430811-67-8 (E)-dimethyl 2-[(R)-2-(4-octylphenethyl)oxiran-2-yl]vinylphosphonate 
• 1430811-68-9 (E)-ethyl 3-[(R)-2-(4-octylphenethyl)oxiran-2-yl]acrylate 
• 1430811-69-0 (S,E)-dimethyl 3-azido-3-(hydroxymethyl)-5-(4-octylphenyl)pent-1-enylphosphonate 
• 1430811-70-3 (R,E)-dimethyl 3-(azidomethyl)-3-hydroxy-5-(4-octylphenyl)pent-1-enylphosphonate 
• 1430811-71-4 (R,E)-ethyl 4-(azidomethyl)-4-hydroxy-6-(4-octylphenyl)hex-2-enoate 
• 1430811-73-6 (S)-5-(4-octylphenethyl)-5-azido-5,6-dihydropyran-2-one 
• 1142015-24-4 (S,E)-dimethyl 3-amino-3-(hydroxymethyl)-5-(4-octylphenyl)pent-1-enylphosphonate 
• 1142015-13-1 (S)-FTY₇₂₀-ene-phosphonate 
• 1430811-61-2 (S,E)-3-azido-3-(hydroxymethyl)-5-(4-octylphenyl)pent-1-enylphosphonic acid 
• 1430811-74-7 (S,E)-dimethyl 3-azido-3-(fluoromethyl)-5-(4-octylphenyl)pent-1-enylphosphonate 

Relevant academic research and scientific papers

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Sphingosine kinase 1 (SK1) is over-expressed in many cancers where it provides a selective growth and survival advantage to these cells. SK1 is thus a target for anti-cancer agents that can promote apoptosis of cancer cells. In previous work, we synthesized a novel allosteric SK1 inhibitor, (S)-FTY720 vinylphosphonate. We now report a more expeditious route to this inhibitor which features B-alkyl Suzuki coupling as a key step and show that replacement of the amino group in (S)-FTY720 vinylphosphonate with an azido group converts the vinylphosphonate from an allosteric inhibitor to an activator of SK1 at low micromolar concentrations. Our results demonstrate the feasibility of using the (S)-FTY720 vinylphosphonate scaffold to define structure-activity relationships in the allosteric site of SK1.

Syndiospecific synthesis of longer p-n-alkyl-substituted polystyrenes using monocyclopentadienyl-type titanium catalysts

Substituted styrenes with linear alkyl substituents (C6 to C12) at the para position on the ring were synthesized and polymerized using the (Me)5CpTi(OMe)3/MAO catalytic system. Increased polymerization activiti

Polystyrene anion exchange polymer pharmaceutical composition

Polystyrene polymers having a quaternised ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is (N,N-dimethyl-N-dodecyl-ammoniomethylstyrene-ethyl methacrylate-divinylbenzene co-polymer,

Polymer compounds

Polymers of structure (I) in which X is a co-monomer unit; X1 is a cross-linking unit; R1 is a saturated or unsaturated C6 to C20 alkyl group; R2 and R3 are the same or different and are each C1 4alky