467471-39-2

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 467471-29-0 (+)-(2S,3R,S_S)-2-(benzylamino)-3-(p-tolylsulfinylamino)pentan-1-ol 

Downstream Products

• 467471-42-7 (-)-(2S,3R)-1-benzyl-3-ethyl-2-hydroxymethylpiperazine 
• 467471-34-7 (+)-(5R,6S)-1-benzyl-5-ethyl-6-hydroxymethylpiperazine-2,3-dione 

Relevant academic research and scientific papers

Synthesis of enantiopure 1-benzyl-2,3-disubstituted piperazines from enantiopure p-toluenesulfinimines

The treatment of enantiopure N-sulfinyl-N′-benzyldiaminoalcohols with diethyl oxalate and sodium methoxide followed by reduction with BH3 affords enantiopure 1-benzyl-2,3-disubstituted piperazines. A related sequence produces substituted monoke

Synthesis of highly substituted enantiopure piperazines and ketopiperazines from vicinal N-sulfinyl diamines

Enantiopure 1-benzyl-2,3-disubstituted piperazines (4) have been synthesized by treatment of N-sulfinyl-N-benzyldiamino alcohols (1) with diethyl oxalate and sodium methoxide followed by reduction with borane. Alternatively, the sulfinamido group was pres