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Fusidine, also known as fusidic acid, is a steroid antibiotic derived from the fungus Fusidium coccineum. It is primarily used to treat bacterial infections, particularly those caused by Staphylococcus aureus, due to its ability to inhibit protein synthesis in bacteria. Fusidine works by binding to the elongation factor G (EF-G) in the bacterial ribosome, which prevents the translocation of the ribosome along the mRNA, ultimately halting protein synthesis. This targeted action makes it effective against gram-positive bacteria while having minimal impact on human cells. However, its use has been limited due to concerns about the development of bacterial resistance and potential side effects, such as liver toxicity.

4680-36-8

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4680-36-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4680-36-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,8 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4680-36:
(6*4)+(5*6)+(4*8)+(3*0)+(2*3)+(1*6)=98
98 % 10 = 8
So 4680-36-8 is a valid CAS Registry Number.

4680-36-8Upstream product

4680-36-8Relevant academic research and scientific papers

Fusidic acid ring B hydroxylation by Cunninghamella elegans

Ibrahim, Abdel-Rahim S.,Ragab, Amany E.

, p. 86 - 89 (2018)

Fusidic acid (1) biotransformation using the fungus Cunninghamella elegans NRRL 1392 was studied. Two hydroxylated derivatives of fusidic acid (2, 3) were isolated, and their structures were fully elucidated using various spectroscopic techniques includin

PREPARATION OF A CRYSTALLINE ANTIBIOTIC SUBSTANCE

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Page/Page column 33-34, (2008/06/13)

The present invention relates to processes for the crystallisation and for the preparation and isolation of a novel crystalline form of fusidic acid, to the use of said processes in the manufacture of pharmaceutical formulation or medicament, and to the use of said crystalline fusidic acid form for the treatment of bacterial infections.

Glycosylated analogs of fusidic acid

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, (2008/06/13)

Novel analogs of fusidic acid are described with one or more carbohydrate units attached. Certain glycosylated analogs of fusidic acid have enhanced solubility properties in diluents or excipient of choice as compared to unmodified fusidic acid. Certain glycosylated analogs may be employed as chemotherapeutic agents and particular analogs may be useful for fighting anti-microbial infections.

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