46804-24-4Relevant academic research and scientific papers
Substituted phenylacetylguanidines: a new class of antihypertensive agents
Bream,Lauener,Picard,Scholtysik,White
, p. 1477 - 1482 (2007/10/05)
The synthesis of a new series of phenylacetylguanidines is described. Several of them exhibited high antihypertensive activity in the rat. The most potent member of the series is N amidino 2 (2,6 dichlorophenyl) acetamide hydrochloride [2,6 dichlorophenylacetylguanidine hydrochloride, compound 19], which is now in clinical study under the clinical code number BS 100-141. The structure activity relationships in this class of compounds are discussed.
