468062-68-2

Upstream product

• 566197-56-6 [(2R,4aR,6R,7S,8S,8aR)-8-Benzyloxy-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy]-triisopropyl-silane 
• 468062-65-9 (2R,4aR,6R,7S,8R,8aR)-8-Benzyloxy-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 566197-57-7 methyl 2-O-triisopropylsilyl-3-O-benzyl-4-O-(4-methoxybenzyl)-6-O-tosyl-β-D-mannopyranoside 
• 468062-66-0 methyl 2-O-triisopropylsilyl-3-O-benzyl-4-O-(4-methoxybenzyl)-β-D-mannopyranoside 
• 468062-64-8 methyl 2,4,6-tri-O-acetyl-3-O-benzyl-β-D-mannopyranoside 
• 566197-55-5 methyl 3-O-benzyl-β-D-mannopyranoside 
• 468062-67-1 methyl 2-O-triisopropylsilyl-3-O-benzyl-4-O-(4-methoxybenzyl)-6-deoxy-6-azido-β-D-mannopyranoside 

Downstream Products

• 468062-70-6 methyl 3-O-benzyl-4-O-(4-methoxybenzyl)-6-deoxy-6-benzyloxycarbonylamino-β-D-mannopyranoside 
• 468062-69-3 methyl 2-O-triisopropylsilyl-3-O-benzyl-4-O-(4-methoxybenzyl)-6-deoxy-6-benzyloxycarbonylamino-β-D-mannopyranoside 

Relevant academic research and scientific papers

Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds

The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.

Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds.

A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing beta-D-mannopyranoside scaffolds is given. The compounds prepared had IC(50) values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.