468717-94-4 Usage
Organic compound
A compound primarily made up of carbon and hydrogen atoms, often containing other elements such as oxygen, nitrogen, and sulfur.
Tosyl group
A tosyl group (-SO2C6H4CH3) is a functional group derived from toluene, consisting of a sulfur dioxide (SO2) group attached to a benzene ring with a methyl group (CH3).
Vinyl group
A vinyl group (-CH=CH2) is a chemical functional group with a carbon-carbon double bond (C=C) and two hydrogen atoms, often used in organic synthesis and polymer chemistry.
Indole ring
An indole ring (C8H7N) is a bicyclic aromatic compound consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring, which is a key structural component in many natural and synthetic compounds.
Carbonitrile group
A carbonitrile group (-C≡N) is a functional group consisting of a carbon atom triple-bonded to a nitrogen atom, often found in nitriles, a class of organic compounds.
Building block in synthesis
TVIC serves as an intermediate compound in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds, providing a foundation for further chemical reactions and modifications.
Biological activities
TVIC has been studied for its potential biological activities, including antimicrobial and antitumor properties, which could lead to the development of new therapeutic agents.
Health hazards
Due to its potential biological activities and chemical reactivity, TVIC may pose health hazards if mishandled or improperly used. It is important to follow proper safety precautions and guidelines when working with 1-tosyl-3-vinyl-1H-indole-5-carbonitrile.
Check Digit Verification of cas no
The CAS Registry Mumber 468717-94-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,8,7,1 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 468717-94:
(8*4)+(7*6)+(6*8)+(5*7)+(4*1)+(3*7)+(2*9)+(1*4)=204
204 % 10 = 4
So 468717-94-4 is a valid CAS Registry Number.
468717-94-4Relevant academic research and scientific papers
Kilogram synthesis of a selective serotonin reuptake inhibitor
Anthes, Robert,Bello, Osagie,Benoit, Serge,Chen, Chien-Kuang,Corbett, Elisabeth,Corbett, Richard M.,DelMonte, Albert J.,Gingras, Stephane,Livingston, Robert,Sausker, Justin,Soumeillant, Maxime
, p. 168 - 177 (2013/01/03)
Process development of a selective serotonin reuptake inhibitor (1) is described. The synthesis features Nishiyama catalystmediated asymmetric cyclopropanation of vinyl indole 2 with ethyldiazoacetate to install the trans-disubstituted cyclopropane. The active pharmaceutical ingredient (1) was prepared in 13 chemical steps with 9 isolations and proceeded in an overall yield of 34%. ? 2008 American Chemical Society.
Catalytic asymmetric diazoacetate cyclopropanation of 1-tosyl-3- vinylindoles. A route to conformationally restricted homotryptamines
Marcin, Lawrence R.,Denhart, Derek J.,Mattson, Ronald J.
, p. 2651 - 2654 (2007/10/03)
(Chemical Equation Presented) Substituted 1-tosyl-3-vinylindoles undergo catalytic asymmetric cyclopropanation with ethyl- and tert-butyldiazoacetate to afford N-protected trans-2-(indol-3-yl)-1-cyclopropanecarboxylic esters in good yield and high enantio
