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AFP464 is a novel small-molecule inhibitor that targets the enzyme poly(ADP-ribose) glycohydrolase (PARG), involved in the repair of damaged DNA. By inhibiting PARG, AFP464 disrupts DNA repair, leading to the accumulation of DNA breaks and causing cell death. This targeted mechanism makes AFP464 a promising candidate for treating various types of cancer, especially in combination with DNA-damaging chemotherapy agents. It also shows potential for treating diseases with DNA repair defects, such as certain leukemias and solid tumors.

468719-52-0

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468719-52-0 Usage

Uses

Used in Oncology:
AFP464 is used as an anticancer agent for its ability to inhibit PARG, disrupting DNA repair and leading to cell death. This makes it a promising treatment for various types of cancer, particularly when used in combination with DNA-damaging chemotherapy agents.
Used in Treating DNA Repair Defect Diseases:
AFP464 is used as a therapeutic agent for diseases characterized by DNA repair defects, such as certain types of leukemia and solid tumors, due to its mechanism of action in inhibiting PARG and disrupting DNA repair.
Clinical trials are ongoing to evaluate the efficacy and safety of AFP464 as a new cancer therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 468719-52-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,8,7,1 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 468719-52:
(8*4)+(7*6)+(6*8)+(5*7)+(4*1)+(3*9)+(2*5)+(1*2)=200
200 % 10 = 0
So 468719-52-0 is a valid CAS Registry Number.

468719-52-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide

1.2 Other means of identification

Product number -
Other names AFP-464 free base

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:468719-52-0 SDS

468719-52-0Upstream product

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