468736-83-6Relevant academic research and scientific papers
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors
Alexander,Warrellow,Eaton,Boyd,Head,Porter,Brown,Reuberson,Hutchinson,Turner,Boyce,Barnes,Mason,Cannell,Taylor,Zomaya,Millican,Leonard,Morphy,Wales,Perry,Allen,Gozzard,Hughes,Higgs
, p. 1451 - 1456 (2007/10/03)
The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC50/su
