468774-16-5

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 132047-92-8 tert-butyl(pent-4-en-1-yloxy)diphenylsilane 
• 87008-76-2 5-(tert-butyldiphenylsilanyloxy)pentane-1,2-diol 
• 821-09-0 n-Pent-4-enyl alcohol 

Downstream Products

• 468774-17-6 4-[3-(tert-butyldiphenylsilanyloxy)propyl]-3H-oxazol-2-one 
• 468774-15-4 trifluoromethanesulfonic acid 4-[3-(tert-butyldiphenylsilanyloxy)propyl]-oxazol-2-yl ester 
• 468774-18-7 (3-{4-[3-(tert-butyldiphenylsilanyloxy)propyl]oxazol-2-yl}prop-2-ynyl)carbamic acid methyl ester 

Relevant academic research and scientific papers

[4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A

Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispyranyl macrolide 3. An efficient assembly and un

Synthesis of the C1'-C11' oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling.

An efficient, convergent synthesis of the C1'-C11' side chain (3) of leucascandrolide A (1) has been achieved. The key bond connection is made through the use of a palladium(0)-catalyzed Sonogashira cross-coupling between trifloyl oxazole (4) and alkynylmetal species (5).