4688-61-3Relevant academic research and scientific papers
Treatment of Olefinic Amides with NBS in Water: Synthesis of Monobromo- A nd Multibromobenzoxazines
Cao, Wen-Bin,Ji, Shun-Jun,Xu, Xiao-Ping,Zhang, Xu
, p. 3805 - 3814 (2019)
Treatment of olefinic amides with N-bromosuccinimide (NBS) in water is reported. Monobromobenzoxazines were mainly formed at room temperature, while at 80? °C multibromobenzoxazines were preferentially generated. Mechanism studies showed that the reaction might proceed via a cascade of electrophilic addition at the C=C bond followed by electrophilic substitution at the aromatic ring. No additives are required in this protocol.
