469-77-2

Usage

Uses

Used in Pharmaceutical Industry:
Spiculisporic acid is used as an antimicrobial agent for its potent antibacterial and antifungal activities. It inhibits the growth of various pathogenic bacteria and fungi, making it a valuable lead compound for the development of new antimicrobial drugs.
Used in Oncology:
Spiculisporic acid is used as an anticancer agent due to its cytotoxicity against various cancer cell lines. Its potential as a therapeutic agent in the treatment of cancer warrants further research and development.
Used in Drug Development:
Spiculisporic acid is used as a lead compound for the development of new antimicrobial and anticancer drugs. Its unique properties and potential therapeutic applications make it a promising candidate for further exploration and innovation in the pharmaceutical industry.

Upstream product

• 500785-90-0 (2S,1'S)-2-(1'-tert-butoxycarbonyl-undec-3'-enyl)-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester 
• 500785-76-2 (2S,1'S)-2-(1'-tert-butoxycarbonyl-3'-oxo-propyl)-5-oxo-2,5-dihydrofuran-2-carboxylic acid methyl ester 
• 440641-47-4 methyl 5‐((triisopropylsilyl)oxy)furan‐2‐carboxylate 
• 66225-22-7 1,1-diiodooctane 
• 500785-91-1 (2S,1'S)-2-(1'-tert-butoxycarbonyl-undecyl)-5-oxo-tetrahydrofuran-2-carboxylic acid methyl ester 
• 96751-13-2 trimethyl (2S,3S)-decylcitrate 

Relevant academic research and scientific papers

The first enantioselective organocatalytic Mukaiyama-Michael reaction: A direct method for the synthesis of enantioenriched γ-butenolide architecture

The first enantioselective organocatalytic Mukaiyama-Michael reaction using α,β-unsaturated aldehydes has been accomplished. The use of iminium catalysis has provided a new strategy for the enantioselective addition of 2-silyloxy furans to unsaturated aldehydes to generate a variety of butenolide systems, an important chiral synthon found among many natural isolates. The (2S,5S)-5-benzyl-2-tert-butyl-imidazolidinone amine catalyst has been found to mediate the conjugate addition of a wide variety of substituted and unsubstituted silyloxy furans to unsaturated aldehydes. A diverse range of aldehyde substrates can be accommodated in this new organocatalytic transformation. Application of this new asymmetric technology to the enantioselective total synthesis of spiculisporic acid and the corresponding 5-epi-spiculisporic acid analogue is also discusse. Copyright

Absolute Configuration and Enantioselective Synthesis of Spiculisporic Acid

The absolute configuration of spiculisporic acid (1), obtained from Penicillium spiculisporum Lehman, has been determined as (3S,4S) by a degradation into (2S,3S)-decylcitric acid (2), a metabolite of a variant of this fungus.The key step in the enantiose