46921-20-4

Basic information

• Product Name: L-Histidine Benzyl Ester
• Synonyms: L-Histidine Benzyl Ester;AXIQMEOYYYWDKF-LBPRGKRZSA-N
• CAS NO: 46921-20-4
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.2771
• Product Categories: Amino Acids & Derivatives, Heterocycles, Inhibitor, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 46921-20-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Histidine Benzyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Histidine Benzyl Ester(46921-20-4)
• EPA Substance Registry System: L-Histidine Benzyl Ester(46921-20-4)

Safety Data

• Hazardous Substances Data: 46921-20-4(Hazardous Substances Data)

Usage

Uses

L-Histidine Benzyl Ester, is a derivative of Histidine (H456010). It has been shown to act as an inhibitor of sweet-almond β-glucosidase, yeast α-glucosidase, and Escherichia coli β-galactosidase. It is also an intermediate for the synthesis of more complex compounds, such as Remikiren (R143550).

Upstream product

• 1332880-89-3 C₂₀H₂₁N₃O₄S 

Downstream Products

• 83283-37-8 Z(OMe)-Ile-Gly-His-OBzl 
• 1219835-33-2 N-((3S)-N-(Boc-L-histidinyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-histidine benzyl ester 
• 1185198-35-9 N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester 
• 1184612-56-3 benzyl (S)-2-(imidazol-4-ylmethyl)-2-(isoquinoline-3-carboxamido)acetate 
• 83283-53-8 (S)-2-[2-((2S,3S)-2-{[(S)-1-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-acetylamino]-3-(1H-imidazol-4-yl)-propionic acid benzyl ester; hydrochloride 
• 83283-38-9 Z(OMe)-Lys(Z)-Pro-Ile-Gly-His-OBzl 
• 83283-50-5 (S)-2-[2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-acetylamino]-3-(1H-imidazol-4-yl)-propionic acid benzyl ester; hydrochloride 

Relevant articles and documents

A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity

Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro-9- (tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycylamino acid benzylesters were provided. On mouse-tail flick model their in vivo analgesic activities were assayed. The results indicate that introducing Gly-OC2H 5 into the 6-position of the substituted purine leads to ambiguous increase of the analgesic activity, while introducing Gly-AA-OBzl into this position leads to significant increase of the analgesic activity.