469889-63-2

Upstream product

• 36653-82-4 1-Hexadecanol 
• 834918-59-1 C₁₆H₁₈N₅O₆P 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Relevant academic research and scientific papers

Novel approach to the synthesis of AZT 5′-O-hydrogen phospholipids

A series of AZT 5′-O-hydrogen phospholipids were synthesized by a tandem transesterification of diphenyl phosphite with AZT and a long-chain alcohol. The method possesses the merits of ease of operation and high yields. It can also be extended to synthesize other biological phospholipids.

Synthesis of AZT 5′-O-hydrogen phospholipids and their derivatives

A series of AZT 5′-O-hydrogen phospholipids 5a-e were synthesized by a tandem transesterification of diphenyl phosphite (DPP) with AZT and a long-chain alcohol. This method has the merits of easy operation and high yields. The corresponding phosphonates, phosphorothionates and phosphoroselenoates of 5d and 5e and the phosphoramidates conjugated with L-amino acid methyl ester 9a and 9b were also synthesized.