469903-96-6

Basic information

• Product Name: 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI)
• Synonyms: 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI)
• CAS NO: 469903-96-6
• Molecular Formula: C₈H₁₂O₂
• Molecular Weight: 140.17968
• Mol File: 469903-96-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI)(469903-96-6)
• EPA Substance Registry System: 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI)(469903-96-6)

Safety Data

• Hazardous Substances Data: 469903-96-6(Hazardous Substances Data)

Usage

General Description

1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI) is a chemical compound with the molecular formula C8H12O2. It is a cyclic ether with an ethynyl group attached to the fourth carbon atom and two methyl groups attached to the second and fifth carbon atoms in the ring. 1,3-Dioxolane, 4-ethynyl-2,2,5-trimethyl-, (4R,5R)- (9CI) belongs to the group of dioxolanes and is commonly used in organic synthesis and as a building block for the production of pharmaceuticals and agrochemicals. In its (4R,5R)- configuration, it exhibits specific stereochemical properties that make it useful for various applications in the chemical industry. This chemical is primarily used as an intermediate in the synthesis of other compounds and is not widely known for its individual properties or uses.

Upstream product

• 99603-55-1 (4S,5R)-2,2,5-trimethyl-1,3-dioxolane-4-carbaldehyde 
• 62170-41-6 (E)-trimethyl(pent-3-en-1-yn-1-yl)silane 
• 73679-54-6 (4R,5R)-5-hydroxymethyl-2,2,4-trimethyl-1,3-dioxolane 
• 163161-10-2 (4R,5R)-4-(2,2-dibromovinyl)-2,2,5-trimethyl-1,3-dioxolane 

Relevant articles and documents

An approach towards C12 oxo analogues of the side chain of pumiliotoxin B/allopumiliotoxin 339A and B

A route towards synthesis of analogues of the pumilotoxin/allopumilotoxin side-chain is described. The C15,C16 diol was introduced by asymmetric dihydroxylation using AD-mix β of C10,C17 eneyneone intermediate 14, or of C13,C17 precursor 17, or by using a chiron-based route from 24. The trisubstituted alkene functionality was established using thioaryl conjugate addition to yneones 16 and 27, followed by a copper-catalyzed stereoretentive reaction with methylmagnesium bromide. The approach enables access to C12 oxo systems and offers an approach towards new C14 analogues.